Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | MAP3K7 | O43318 | 6/20 | 0.38 |
| ▸ | TAB1 | Q15750 | 6/20 | 0.38 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 2/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.30 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.30 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.30 |
| ▸ | PAK4 | O96013 | 1/20 | 0.30 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.30 |
| ▸ | PRKACA | P17612 | 1/20 | 0.30 |
| ▸ | LTK | P29376 | 1/20 | 0.30 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.30 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.30 |
| ▸ | CDK8 | P49336 | 1/20 | 0.30 |
| ▸ | CLK2 | P49760 | 1/20 | 0.30 |
| ▸ | GSK3A | P49840 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL311539 | 0.82 | CHEK1 (0.46) | CHEK1MAP3K7TAB1CHUKAURKA | |
| SCHEMBL1735020 | 0.77 | CHEK1 (0.50) | CHEK1MAP3K7TAB1CHUKTRPA1 | |
| SCHEMBL310980 | 0.76 | CHEK1 (0.43) | CHEK1MAP3K7TAB1CHUKTRPA1 | |
| SCHEMBL312426 | 0.71 | CHEK1 (0.49) | CHEK1MAP3K7TAB1CHUKAURKA | |
| SCHEMBL154683 | 0.70 | CHUK (0.61) | CHEK1MAP3K7TAB1CHUKLRRK2 | |
| SCHEMBL1737697 | 0.70 | CHEK1 (0.56) | CHEK1MAP3K7TAB1CHUKTRPA1 | |
| SCHEMBL5522262 | 0.70 | CHEK1 (0.47) | CHEK1CHUKLRRK2PRKD3MAP4K4 | |
| SCHEMBL30974784 | 0.67 | CHEK1 (0.56) | CHEK1MAP3K7TAB1TRPA1AURKA | |
| SCHEMBL15598602 | 0.65 | CHEK1 (0.53) | CHEK1TRPA1AURKAAKT1LRRK2 | |
| SCHEMBL357993 | 0.65 | CHEK1 (0.61) | CHEK1TRPA1AURKAAKT1ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2148880-B1 | P70 S6 KINASE INHIBITORS | LILLY CO ELI (US) | 2014-05-28 | — | — | EP | disclosed |
| US-20120071490-A1 | P70 S6 KINASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2012-03-22 | — | — | US | disclosed |
| US-8093383-B2 | P70 S6 kinase inhibitors | ELI LILLY AND COMPANY (US) | 2012-01-10 | — | — | US | disclosed |
| US-20090163714-A1 | P70 S6 KINASE INHIBITORS | ELI LILLY AND COMPANY | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163714-A1 | P70 S6 KINASE INHIBITORS | RPS6KA6, RPS6KA1, RPS6KA2 | CHEK1 521/4885MAP3K7 110/4885TAB1 1578/4885 |
| US-20120071490-A1 | P70 S6 KINASE INHIBITORS | RPS6KA6, RPS6KA1, RPS6KA2 | CHEK1 521/4885MAP3K7 110/4885TAB1 1578/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.