Sugi Predict

Sugi Predict / Compounds / SCHEMBL154683

SCHEMBL154683

SCHEMBL154683

N#Cc1c[nH]c2ncnc(Cl)c12

nearest known ligand 0.61

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ CHUK O15111 3/20 0.61
▸ LRRK2 Q5S007 7/20 0.58
▸ CHEK1 O14757 1/20 0.56
▸ MAP3K7 O43318 1/20 0.52
▸ TAB1 Q15750 1/20 0.52
▸ HSP90AB1 P08238 1/20 0.49
▸ ROCK2 O75116 6/20 0.47
▸ ROCK1 Q13464 6/20 0.47
▸ CDC42BPB Q9Y5S2 6/20 0.47
▸ CDC42BPA Q5VT25 4/20 0.47
▸ IRAK4 Q9NWZ3 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1737697 0.82 CHEK1 (0.56) CHUKLRRK2CHEK1MAP3K7TAB1
Toyocamycin Aglycone SCHEMBL7698538 0.80 MAP3K7 (0.54) CHUKLRRK2MAP3K7TAB1HSP90AB1
SCHEMBL14649086 0.79 MAP3K7 (0.56) CHUKLRRK2MAP3K7TAB1HSP90AB1
SCHEMBL1735020 0.77 CHEK1 (0.50) CHUKLRRK2CHEK1MAP3K7TAB1
SCHEMBL19185239 0.76 MAP3K7 (0.54) CHUKLRRK2MAP3K7TAB1HSP90AB1
SCHEMBL312426 0.76 CHEK1 (0.49) CHUKLRRK2CHEK1MAP3K7TAB1
SCHEMBL19010829 0.75 CHUK (0.71) CHUKLRRK2HSP90AB1ROCK2ROCK1
SCHEMBL31095312 0.75 CHUK (0.71) CHUKLRRK2HSP90AB1ROCK2ROCK1
SCHEMBL1598149 0.75 CHEK1 (0.66) LRRK2CHEK1
SCHEMBL31329069 0.75 CHEK1 (0.66) LRRK2CHEK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 271 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113354650-B Preparation method of 4-chloro-7H-pyrrolo [2,3-d ] pyrimidine-5-carbonitrile 安徽大学 2023-12-19 — — CN claimed
CN-113354650-A Preparation method of 4-chloro-7H-pyrrolo [2,3-d ] pyrimidine-5-carbonitrile 安徽大学 2021-09-07 — — CN claimed
US-20260028328-A1 HETEROARYL DERIVATIVES AS DDRs INHIBITORS CHIESI FARMACEUTICI S.P.A. (IT) 2026-01-29 — — US disclosed
US-12485109-B2 Pyrrolo 12.3-dipyrimidine compounds and analogues thereof BIOCRYST PHARMACEUTICALS, INC. (US) 2025-12-02 — — US disclosed
US-20250170122-A1 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS INTELLIKINE LLC (US) 2025-05-29 — — US disclosed
EP-4558490-A1 HETEROARYL DERIVATIVES AS DDRS INHIBITORS Chiesi Farmaceutici S.p.A. (IT) 2025-05-28 — — EP disclosed
US-20250134869-A1 Pyrrolo[2,3-d]pyrimidinyl, Pyrrolo[2,3-b]pyrazinyl and Pyrrolo[2,3-d]pyridinyl Acryla-mides PFIZER INC (US) 2025-05-01 — — US disclosed
CN-119562946-A Heteroaryl derivatives as DDR inhibitors 奇斯药制品公司 2025-03-04 — — CN disclosed
US-12077533-B2 Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl and pyrrolo[2,3-d]pyridinyl acrylamides PFIZER INC. (US) 2024-09-03 — — US disclosed
CN-116496283-B Pentaaza acenaphthene compound, preparation method, pharmaceutical composition and application 中国药科大学 2024-04-19 — — CN disclosed
EP-3925956-B1 1H-INDAZOLE-3-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS FACTOR D INHIBITORS FOR TREATING DISEASES CHARACTERIZED BY ABERRANT COMPLEMENT SYSTEM ACTIVITY, SUCH AS E.G. IMMUNOLOGICAL DISORDERS BIOCRYST PHARM INC (US) 2024-04-10 — — EP disclosed
WO-1999065909-A1 PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS PFIZER PRODUCTS INC. (US) 1999-12-23 — — WO disclosed
WO-1999065908-A1 PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS PFIZER PRODUCTS INC. (US) 1999-12-23 — — WO disclosed
EP-0496617-B1 Adenosine kinase inhibitors METABASIS THERAPEUTICS INC (US) 1999-12-01 — — EP disclosed
EP-0831829-A4 HETEROCYCLIC RING-FUSED PYRIMIDINE DERIVATIVES PFIZER (US) 1998-11-25 — — EP disclosed
EP-0831829-A1 HETEROCYCLIC RING-FUSED PYRIMIDINE DERIVATIVES PFIZER INC. (US) 1998-04-01 — — EP disclosed
US-5646128-A TREATING INFLAMMATION, SEPSIS, SEPTIC SHOCK, BURNS GENSIA, INC. (US) 1997-07-08 — — US disclosed
WO-1996040142-A1 HETEROCYCLIC RING-FUSED PYRIMIDINE DERIVATIVES PFIZER INC. (US) 1996-12-19 — — WO disclosed
WO-1992012718-A1 ADENOSINE KINASE INHIBITORS GENSIA, INC. (US) 1992-08-06 — — WO disclosed
EP-0496617-A1 Adenosine kinase inhibitors GENSIA, INC. (US) 1992-07-29 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12485109-B2 Pyrrolo 12.3-dipyrimidine compounds and analogues thereof C5, DPYD, C9 CHUK 108/4885LRRK2 2287/4885CHEK1 1082/4885
US-12077533-B2 Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl and pyrrolo[2,3-d]pyridinyl acrylamides ACR, PKD2, PGA5 CHUK 1268/4885LRRK2 4346/4885CHEK1 718/4885
US-20250134869-A1 Pyrrolo[2,3-d]pyrimidinyl, Pyrrolo[2,3-b]pyrazinyl and Pyrrolo[2,3-d]pyridinyl Acryla-mides JAK2, JAK3, JAK1 CHUK 271/4885LRRK2 1563/4885CHEK1 339/4885
US-20250170122-A1 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS PIK3CA, PIK3CG, PIK3CB CHUK 836/4885LRRK2 712/4885CHEK1 226/4885
US-20260028328-A1 HETEROARYL DERIVATIVES AS DDRs INHIBITORS DDR1, DDR2, DDRGK1 CHUK 2876/4885LRRK2 97/4885CHEK1 18/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.