Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | HCRTR2 | O43614 | 10/20 | 0.52 |
| ▸ | HCRTR1 | O43613 | 7/20 | 0.52 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.51 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.45 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.44 |
| ▸ | CCR3 | P51677 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL835093 | 0.86 | KMT2A (0.64) | MEN1KMT2AHCRTR2HCRTR1RIPK1 | |
| SCHEMBL12654456 | 0.84 | KMT2A (0.62) | MEN1KMT2AHCRTR2HCRTR1RIPK1 | |
| SCHEMBL28978295 | 0.84 | MEN1 (0.58) | MEN1KMT2AHCRTR2HCRTR1RIPK1 | |
| SCHEMBL16488087 | 0.83 | MEN1 (0.56) | MEN1KMT2AHCRTR2HCRTR1RIPK1 | |
| SCHEMBL21315254 | 0.83 | KMT2A (0.56) | MEN1KMT2AHCRTR2HCRTR1RIPK1 | |
| SCHEMBL2629508 | 0.82 | MEN1 (0.52) | MEN1KMT2AHCRTR2HCRTR1RIPK1 | |
| SCHEMBL3723506 | 0.82 | KMT2A (0.55) | MEN1KMT2AHCRTR2HCRTR1RIPK1 | |
| SCHEMBL22447793 | 0.81 | MEN1 (0.54) | MEN1KMT2AHCRTR2HCRTR1RIPK1 | |
| SCHEMBL4068492 | 0.81 | RIPK1 (0.64) | MEN1KMT2AHCRTR2HCRTR1RIPK1 | |
| SCHEMBL20390892 | 0.81 | MEN1 (0.54) | MEN1KMT2AHCRTR2HCRTR1RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |