Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | DDO | Q99489 | 1/20 | 0.32 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.31 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.30 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 2/20 | 0.30 |
| ▸ | NOS2 | P35228 | 2/20 | 0.30 |
| ▸ | PARP1 | P09874 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27113640 | 0.81 | KCNH2 (0.45) | KCNH2DYRK1AMAP4K4SLC2A1NOS1 | |
| SCHEMBL20069151 | 0.79 | KCNH2 (0.46) | KCNH2DYRK1AALDH1A1 | |
| SCHEMBL13279624 | 0.79 | NOS1 (0.43) | DYRK1AKDM4EMEN1ALDH1A1LMNA | |
| SCHEMBL18252807 | 0.78 | KCNH2 (0.45) | KCNH2DYRK1A | |
| SCHEMBL17827395 | 0.78 | KCNH2 (0.45) | KCNH2DYRK1AALDH1A1SLC2A1PARP1 | |
| SCHEMBL13428824 | 0.78 | KCNH2 (0.55) | KCNH2DYRK1AMAP4K4NOS1 | |
| SCHEMBL31226701 | 0.76 | KDR (0.35) | DYRK1AKDM4EMEN1ALDH1A1LMNA | |
| SCHEMBL14478360 | 0.75 | KCNH2 (0.43) | KCNH2DYRK1AKDM4EMEN1ALDH1A1 | |
| SCHEMBL24533969 | 0.75 | NOS1 (0.36) | KDM4EMEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL6641420 | 0.74 | KCNH2 (0.40) | KCNH2DYRK1AMAP4K4SLC2A1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4709712-A1 | GSK3A INHIBITORS AND METHODS OF USE THEREOF | Blueprint Medicines Corporation (US) | 2026-03-18 | — | — | EP | disclosed |
| WO-2024233900-A1 | GSK3A INHIBITORS AND METHODS OF USE THEREOF | BLUEPRINT MEDICINES CORPORATION (US) | 2024-11-14 | — | — | WO | disclosed |