Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 1/20 | 0.46 |
| ▸ | STS | P08842 | 1/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31228493 | 1.00 | KLK7 (0.46) | KLK7STSHCRTR2GPR119PARP1 | |
| SCHEMBL31228495 | 1.00 | KLK7 (0.46) | KLK7STSHCRTR2GPR119PARP1 | |
| SCHEMBL31228447 | 0.92 | KLK7 (0.48) | KLK7STSHCRTR2GPR119PARP1 | |
| SCHEMBL31228705 | 0.92 | KLK7 (0.48) | KLK7STSHCRTR2GPR119PARP1 | |
| SCHEMBL7301938 | 0.87 | KLK7 (0.47) | KLK7STSHCRTR2GPR119PARP1 | |
| SCHEMBL31228339 | 0.85 | KLK7 (0.46) | KLK7STSHCRTR2GPR119PARP1 | |
| SCHEMBL31153726 | 0.84 | KLK7 (0.46) | KLK7STSHCRTR2GPR119PARP1 | |
| SCHEMBL7921496 | 0.83 | KLK7 (0.47) | KLK7STSGPR119PARP1JAK2 | |
| SCHEMBL7921498 | 0.83 | KLK7 (0.47) | KLK7STSGPR119PARP1JAK2 | |
| SCHEMBL27782500 | 0.82 | SMN1; SMN2 (0.46) | KLK7STSGPR119PARP1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4688789-A1 | MACROCYCLIC RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2026-02-11 | — | — | EP | disclosed |
| WO-2024211663-A9 | MACROCYCLIC RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2025-01-30 | — | — | WO | disclosed |
| WO-2024211663-A1 | CONDENSED MACROCYCLIC COMPOUNDS AS RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2024-10-10 | — | — | WO | disclosed |