Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 1/20 | 0.47 |
| ▸ | STS | P08842 | 1/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL35210538 | 0.88 | NR1H2 (0.42) | KLK7STSJAK2JAK1PARP1 | |
| SCHEMBL31228337 | 0.87 | KLK7 (0.46) | KLK7STSHCRTR2GPR119JAK2 | |
| SCHEMBL31228493 | 0.87 | KLK7 (0.46) | KLK7STSHCRTR2GPR119JAK2 | |
| SCHEMBL31228495 | 0.87 | KLK7 (0.46) | KLK7STSHCRTR2GPR119JAK2 | |
| SCHEMBL30335837 | 0.87 | L3MBTL1 (0.47) | KLK7STSGPR119L3MBTL1 | |
| SCHEMBL31228705 | 0.86 | KLK7 (0.48) | KLK7STSHCRTR2GPR119JAK2 | |
| SCHEMBL31228339 | 0.86 | KLK7 (0.46) | KLK7STSHCRTR2GPR119JAK2 | |
| SCHEMBL31228447 | 0.86 | KLK7 (0.48) | KLK7STSHCRTR2GPR119JAK2 | |
| SCHEMBL29997998 | 0.85 | NR1H2 (0.46) | KLK7STSHCRTR2GPR119JAK2 | |
| SCHEMBL29997912 | 0.85 | NR1H2 (0.46) | KLK7STSHCRTR2GPR119JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5629406-A | AMINO ACID DERIVATIVES | SANKYO COMPANY, LIMITED (JP) | 1997-05-13 | — | — | US | disclosed |
| EP-0587311-A1 | Peptides capable of inhibiting the activity of HIV protease, their preparation and their therapeutic use | SANKYO COMPANY LIMITED (JP) | 1994-03-16 | — | — | EP | disclosed |