Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 2/20 | 0.33 |
| ▸ | CTSS | P25774 | 2/20 | 0.33 |
| ▸ | CTSB | P07858 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL419892 | 0.85 | TSHR (0.47) | TSHRGAANPBWR1KMT2ANPSR1 | |
| SCHEMBL18079514 | 0.85 | TSHR (0.50) | TSHRGAANPBWR1KMT2ANPSR1 | |
| SCHEMBL18765554 | 0.85 | TSHR (0.50) | TSHRGAANPBWR1KMT2ANPSR1 | |
| SCHEMBL8936167 | 0.79 | MAOB (0.51) | TSHRGAANPBWR1KMT2ANPSR1 | |
| SCHEMBL8936171 | 0.79 | MAOB (0.51) | TSHRGAANPBWR1KMT2ANPSR1 | |
| SCHEMBL17986870 | 0.77 | TSHR (0.44) | TSHRGAANPBWR1KMT2ANPSR1 | |
| SCHEMBL26820046 | 0.72 | NR1H2 (0.35) | TSHRALDH1A1MAOBLMNAKDM4E | |
| SCHEMBL26670299 | 0.72 | NR1H2 (0.35) | TSHRALDH1A1MAOBLMNAKDM4E | |
| SCHEMBL5390976 | 0.71 | TSHR (0.44) | TSHRGAANPBWR1KMT2ANPSR1 | |
| SCHEMBL13452589 | 0.71 | ADRA2B (0.50) | TSHRGAANPBWR1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4688789-A1 | MACROCYCLIC RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2026-02-11 | — | — | EP | disclosed |
| WO-2024211663-A9 | MACROCYCLIC RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2025-01-30 | — | — | WO | disclosed |
| WO-2024211663-A1 | CONDENSED MACROCYCLIC COMPOUNDS AS RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2024-10-10 | — | — | WO | disclosed |