⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5081792 | 0.85 | TSHR (0.31) | — | |
| SCHEMBL15141679 | 0.81 | CYP2D6 (0.41) | — | |
| SCHEMBL223234 | 0.76 | NUDT1 (0.33) | — | |
| SCHEMBL6450963 | 0.76 | — | — | |
| SCHEMBL2523718 | 0.76 | — | — | |
| SCHEMBL1369695 | 0.76 | — | — | |
| SCHEMBL5075125 | 0.76 | NUDT1 (0.31) | — | |
| SCHEMBL15141647 | 0.74 | — | — | |
| SCHEMBL2152288 | 0.74 | CYP2C19 (0.32) | — | |
| SCHEMBL6555272 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4688789-A1 | MACROCYCLIC RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2026-02-11 | — | — | EP | disclosed |
| WO-2024211663-A9 | MACROCYCLIC RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2025-01-30 | — | — | WO | disclosed |
| WO-2024211663-A1 | CONDENSED MACROCYCLIC COMPOUNDS AS RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2024-10-10 | — | — | WO | disclosed |