⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15050014 | 0.94 | ALDH1A1 (0.33) | — | |
| Tromethamine SCHEMBL23041034 | 0.85 | ALDH1A1 (0.36) | — | |
| Tromethamine SCHEMBL49209 | 0.85 | ALDH1A1 (0.36) | — | |
| Tromethamine SCHEMBL6320590 | 0.84 | ALDH1A1 (0.35) | — | |
| SCHEMBL15023848 | 0.81 | ALDH1A1 (0.33) | — | |
| SCHEMBL3717128 | 0.79 | ALDH1A1 (0.43) | — | |
| SCHEMBL1232551 | 0.77 | ALDH1A1 (0.33) | — | |
| SCHEMBL2417 | 0.77 | ALDH1A1 (0.45) | — | |
| SCHEMBL2229127 | 0.77 | ALDH1A1 (0.45) | — | |
| SCHEMBL9790 | 0.77 | ALDH1A1 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9701686-B2 | Tricyclopyrazole derivatives | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2017-07-11 | — | — | US | disclosed |
| US-20150329552-A1 | TRICYCLOPYRAZOLE DERIVATIVES | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2015-11-19 | — | — | US | disclosed |
| US-9127015-B2 | Tricyclopyrazole derivatives | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2015-09-08 | — | — | US | disclosed |
| US-8981092-B2 | Substituted 3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-1-ones as modulators of protein kinase activity | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2015-03-17 | — | — | US | disclosed |
| US-8772279-B2 | 6,7-dihydroimidazo[1,5-a]pyrazin-8(5H)-one derivatives as protein kinase modulators | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2014-07-08 | — | — | US | disclosed |
| US-8513241-B2 | 3,4-dihydro-2H-pyrazino[1,2-A]indol-1-one derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2013-08-20 | — | — | US | disclosed |
| US-20130137696-A1 | 3,4-DIHYDRO-2H-PYRROLO[1,2-A]PYRAZIN-1-ONE DERIVATIVES FOR THE MODULATION OF THE ACTIVITY OF PROTEIN KINASES | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2013-05-30 | — | — | US | disclosed |
| US-20130029974-A1 | 6,7-DIHYDROIMIDAZO[1,5-A]PYRAZIN-8(5H)-ONE DERIVATIVES AS PROTEIN KINASE MODULATORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2013-01-31 | — | — | US | disclosed |
| EP-2528918-A1 | 6,7- DIHYDROIMIDAZO [1,5-A]PYRAZIN-8 (5H) - ONE DERIVATIVES AS PROTEIN KINASE MODULATORS | Nerviano Medical Sciences S.r.l. (IT) | 2012-12-05 | — | — | EP | disclosed |
| US-20120277214-A1 | TRICYCLOPYRAZOLE DERIVATIVES | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-11-01 | — | — | US | disclosed |
| EP-2507244-A1 | TRICYCLOPYRAZOLE DERIVATIVES | Nerviano Medical Sciences S.r.l. (IT) | 2012-10-10 | — | — | EP | disclosed |
| US-20120232085-A1 | 3,4-DIHYDRO-2H-PYRAZINO[1,2-A]INDOL-1-ONE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-09-13 | — | — | US | disclosed |
| EP-2254886-A2 | 3,4-DIHYDRO-2H-PYRAZINOÝ1,2-A¨INDOL-1-ONE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Nerviano Medical Sciences S.r.l. (IT) | 2010-12-01 | — | — | EP | disclosed |
| WO-2010031816-A1 | 3,4 DIHYDRO-2H-PYRROLO[1,2-a]PYRAZIN-1-ONE DERIVATIVES | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2010-03-25 | — | — | WO | disclosed |
| WO-2009118411-A2 | 3,4-DIHYDRO-2H-PYRAZINO[1,2-A]INDOL-1-ONE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2009-10-01 | — | — | WO | disclosed |