SCHEMBL31233147

SCHEMBL31233147

O=C(C=Cc1ccc(O)c(Cl)c1)c1ccc(F)cc1F

nearest known ligand 0.61

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAOB P27338 3/20 0.61
CXCL12 P48061 2/20 0.58
GUSB P08236 1/20 0.54
PTGS1 P23219 1/20 0.52
PTGS2 P35354 1/20 0.52
MAPT P10636 1/20 0.51
NPSR1 Q6W5P4 1/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
P4HB P07237 2/20 0.51
MEN1 O00255 1/20 0.50
LMNA P02545 1/20 0.50
HPGD P15428 1/20 0.50
KMT2A Q03164 1/20 0.50
BACE1 P56817 1/20 0.50
MAOA P21397 1/20 0.49
TERT O14746 1/20 0.49
CTSL P07711 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25218131 1.00 MAOB (0.61) MAOBCXCL12GUSBPTGS1PTGS2
SCHEMBL25231544 1.00 MAOB (0.61) MAOBCXCL12GUSBPTGS1PTGS2
SCHEMBL31233418 1.00 MAOB (0.61) MAOBCXCL12GUSBPTGS1PTGS2
SCHEMBL30384947 0.84 MAPT (0.58) MAOBCXCL12MAPTNPSR1L3MBTL1
SCHEMBL25214713 0.84 MAPT (0.58) MAOBCXCL12MAPTNPSR1L3MBTL1
SCHEMBL30384093 0.84 MAPT (0.58) MAOBCXCL12MAPTNPSR1L3MBTL1
SCHEMBL25197224 0.84 MAPT (0.58) MAOBCXCL12MAPTNPSR1L3MBTL1
SCHEMBL31233123 0.82 TNFRSF1A (0.66) CXCL12PTGS2MAPTBACE1TERT
SCHEMBL25192175 0.82 TNFRSF1A (0.66) CXCL12PTGS2MAPTBACE1TERT
SCHEMBL25204119 0.82 TNFRSF1A (0.66) CXCL12PTGS2MAPTBACE1TERT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024233598-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2024-11-14 WO disclosed