Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | IAPP | P10997 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | FDPS | P14324 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8545871 | 0.79 | KDM4E (0.72) | TDP1GLAKDM4EMAPK1SMN1; SMN2 | |
| SCHEMBL8545869 | 0.79 | KDM4E (0.72) | TDP1GLAKDM4EMAPK1SMN1; SMN2 | |
| SCHEMBL13476341 | 0.78 | TDP1 (0.57) | TDP1GLAKDM4EMAPK1SMN1; SMN2 | |
| SCHEMBL1359336 | 0.76 | GLA (0.77) | TDP1GLAKDM4EMAPK1IAPP | |
| SCHEMBL1359335 | 0.76 | GLA (0.77) | TDP1GLAKDM4EMAPK1IAPP | |
| SCHEMBL25524702 | 0.75 | NPC1 (0.60) | TDP1GLAKDM4EMAPK1SMN1; SMN2 | |
| SCHEMBL6851909 | 0.74 | KDM4E (0.65) | KDM4EMAPK1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL29090920 | 0.74 | GLA (0.57) | TDP1GLAKDM4EMAPK1SMN1; SMN2 | |
| SCHEMBL20125118 | 0.72 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9APOLBLMNA | |
| SCHEMBL18713537 | 0.70 | KDM4E (0.69) | KDM4EMAPK1SMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012025182-A1 | SWITCH ELEMENT COMPRISING A LIQUID-CRYSTALLINE MEDIUM | MERCK PATENT GMBH (DE) | 2012-03-01 | — | — | WO | disclosed |