SCHEMBL31237129

SCHEMBL31237129

Nc1c[nH]nc1-c1cc(Cl)ccc1[N+](=O)[O-]

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 2/20 0.45
TSHR P16473 2/20 0.45
PDE7A Q13946 9/20 0.44
MAPT P10636 4/20 0.42
MEN1 O00255 3/20 0.42
KMT2A Q03164 3/20 0.42
HPGD P15428 1/20 0.42
PDE7B Q9NP56 2/20 0.41
TDP1 Q9NUW8 4/20 0.38
POLB P06746 2/20 0.38
ALDH1A1 P00352 2/20 0.38
CYP3A4 P08684 1/20 0.38
ALOX15 P16050 1/20 0.38
PDE4B Q07343 1/20 0.38
PDE4D Q08499 1/20 0.38
MITF O75030 1/20 0.38
LMNA P02545 1/20 0.38
CACNA1B Q00975 1/20 0.38
APBA1 Q02410 1/20 0.38
MCL1 Q07820 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10771873 0.75 MAPK1 (0.53) MAPK1TSHRPDE7AMAPTMEN1
SCHEMBL11516745 0.75 MAPK1 (0.69) MAPK1TSHRPDE7AMAPTMEN1
SCHEMBL10769072 0.74 MAPT (0.44) TSHRMAPTKMT2AHPGDALDH1A1
SCHEMBL12943009 0.72 ALDH1A1 (0.50) TSHRMAPTMEN1KMT2AHPGD
SCHEMBL5415102 0.72 PDE7A (0.58) MAPK1TSHRPDE7AMAPTMEN1
SCHEMBL112538 0.71 TDP1 (0.64) MAPK1TSHRPDE7AMAPTMEN1
4-Chloro-2-Nitroaniline SCHEMBL131251 0.71 TDP1 (0.64) MAPK1TSHRPDE7AMAPTMEN1
SCHEMBL30408194 0.71 TDP1 (0.64) MAPK1TSHRPDE7AMAPTMEN1
SCHEMBL10566808 0.71 MAPT (0.43) MAPK1TSHRPDE7AMAPTMEN1
SCHEMBL9566423 0.71 HTR2B (0.58) MAPK1TSHRPDE7AMAPTHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024201308-A1 NOVEL BENZIMIDAZOLONE DERIVATIVE COMPOUND AS AUTOTAXIN INHIBITOR 주식회사 엘지화학 2024-10-03 WO disclosed