Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.50 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 4/20 | 0.41 |
| ▸ | HTR2B | P41595 | 4/20 | 0.41 |
| ▸ | HRH1 | P35367 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12175733 | 0.89 | HTR1A (0.47) | HTR1ASLC6A2SLC6A3PIM1HTR2C | |
| SCHEMBL2302295 | 0.89 | HTR1A (0.47) | HTR1ASLC6A2SLC6A3PIM1HTR2C | |
| SCHEMBL3121175 | 0.80 | HRH1 (0.45) | HTR1ASLC6A2SLC6A3HTR2CHTR2B | |
| SCHEMBL1673897 | 0.80 | HRH1 (0.59) | PIM1HTR2CHRH1EPHX1 | |
| SCHEMBL1231184 | 0.79 | SLC6A2 (0.52) | HTR1ASLC6A2SLC6A3HTR2CHTR2B | |
| SCHEMBL83203 | 0.79 | SLC6A2 (0.62) | HTR1ASLC6A2SLC6A3HTR2CHTR2B | |
| SCHEMBL941224 | 0.78 | HRH1 (0.57) | HTR1ASLC6A2SLC6A3PIM1HRH1 | |
| SCHEMBL29995496 | 0.78 | HRH1 (0.57) | HTR1ASLC6A2SLC6A3PIM1HRH1 | |
| Hydrochloric Acid SCHEMBL69817 | 0.77 | HTR1A (0.60) | HTR1ASLC6A2SLC6A3HTR2CHTR2B | |
| Potassium Ion SCHEMBL3634494 | 0.77 | HRH1 (0.56) | PIM1HTR2CHRH1EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |