Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 17/20 | 0.62 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.58 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.57 |
| ▸ | PRKACA | P17612 | 5/20 | 0.53 |
| ▸ | PRKACG | P22612 | 5/20 | 0.53 |
| ▸ | PRKACB | P22694 | 5/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3247609 | 0.95 | ROCK2 (0.60) | ROCK2ROCK1CDC42BPAPRKACAPRKACG | |
| SCHEMBL3250349 | 0.91 | ROCK2 (0.63) | ROCK2ROCK1CDC42BPAPRKACAPRKACG | |
| SCHEMBL3241015 | 0.91 | ROCK2 (0.63) | ROCK2ROCK1CDC42BPAPRKACAPRKACG | |
| SCHEMBL3241375 | 0.90 | ROCK2 (0.68) | ROCK2ROCK1CDC42BPAPRKACAPRKACG | |
| SCHEMBL3241104 | 0.89 | ROCK2 (0.62) | ROCK2ROCK1CDC42BPAPRKACAPRKACG | |
| SCHEMBL3249977 | 0.88 | ROCK2 (0.75) | ROCK2ROCK1PRKACAPRKACGPRKACB | |
| SCHEMBL3240430 | 0.88 | ROCK2 (0.61) | ROCK2ROCK1CDC42BPAPRKACAPRKACG | |
| SCHEMBL3127171 | 0.88 | ROCK2 (0.74) | ROCK2ROCK1CDC42BPAPRKACAPRKACG | |
| SCHEMBL3252386 | 0.87 | ROCK2 (0.57) | ROCK2ROCK1CDC42BPA | |
| SCHEMBL3244445 | 0.83 | ROCK2 (0.58) | ROCK2ROCK1PRKACAPRKACGPRKACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010036316-A1 | UREA AND CARBAMATE COMPOUNDS AND ANALOGS AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-04-01 | — | — | WO | claimed |
| WO-2010036316-A1 | UREA AND CARBAMATE COMPOUNDS AND ANALOGS AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-04-01 | — | — | WO | disclosed |