Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 20/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 16/20 | 0.48 |
| ▸ | GSK3B | P49841 | 8/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3131592 | 0.87 | CDK2 (0.46) | CDK2CCNE1GSK3BCCNA2CCNA1 | |
| SCHEMBL3131586 | 0.87 | CDK2 (0.46) | CDK2CCNE1GSK3BCCNA2CCNA1 | |
| SCHEMBL3125243 | 0.84 | CDK2 (0.53) | CDK2CCNE1GSK3B | |
| SCHEMBL3125245 | 0.84 | CDK2 (0.53) | CDK2CCNE1GSK3B | |
| SCHEMBL3124519 | 0.83 | CCNE1 (0.53) | CDK2CCNE1GSK3B | |
| SCHEMBL3122489 | 0.83 | CDK2 (0.51) | CDK2CCNE1GSK3B | |
| SCHEMBL3122495 | 0.83 | CDK2 (0.51) | CDK2CCNE1GSK3B | |
| SCHEMBL3127323 | 0.80 | PTGER1 (0.37) | CDK2CCNE1GSK3B | |
| SCHEMBL3254151 | 0.79 | CDK2 (0.45) | CDK2CCNE1GSK3BCCNA2CCNA1 | |
| SCHEMBL3127039 | 0.77 | NPY2R (0.36) | CDK2CCNE1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689721-B1 | AMINOPYRAZOLE DERIVATIVES AS GSK-3 INHIBITORS | PFIZER PROD INC (US) | 2010-07-14 | — | — | EP | disclosed |
| US-7671072-B2 | Aminopyrazole derivatives as GSK-3 inhibitors | PFIZER INC. (US) | 2010-03-02 | — | — | US | disclosed |
| US-20070276010-A1 | Aminopyrazole Derivatives as Gsk-3 Inhibitors | BENBOW JOHN W | 2007-11-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070276010-A1 | Aminopyrazole Derivatives as Gsk-3 Inhibitors | GSK3B, GSK3A, GSKIP | CDK2 58/4885CCNE1 420/4885GSK3B 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.