Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 20/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 19/20 | 0.53 |
| ▸ | GSK3B | P49841 | 6/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3125245 | 1.00 | CDK2 (0.53) | CDK2CCNE1GSK3B | |
| SCHEMBL3122489 | 0.86 | CDK2 (0.51) | CDK2CCNE1GSK3B | |
| SCHEMBL3122495 | 0.86 | CDK2 (0.51) | CDK2CCNE1GSK3B | |
| SCHEMBL3124519 | 0.84 | CCNE1 (0.53) | CDK2CCNE1GSK3B | |
| SCHEMBL3124512 | 0.84 | CDK2 (0.48) | CDK2CCNE1GSK3B | |
| SCHEMBL3131586 | 0.82 | CDK2 (0.46) | CDK2CCNE1GSK3B | |
| SCHEMBL3131592 | 0.82 | CDK2 (0.46) | CDK2CCNE1GSK3B | |
| SCHEMBL3133459 | 0.79 | CDK2 (0.49) | CDK2CCNE1GSK3B | |
| SCHEMBL3133467 | 0.79 | CDK2 (0.49) | CDK2CCNE1GSK3B | |
| SCHEMBL3254151 | 0.79 | CDK2 (0.45) | CDK2CCNE1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689721-B1 | AMINOPYRAZOLE DERIVATIVES AS GSK-3 INHIBITORS | PFIZER PROD INC (US) | 2010-07-14 | — | — | EP | claimed |
| US-7671072-B2 | Aminopyrazole derivatives as GSK-3 inhibitors | PFIZER INC. (US) | 2010-03-02 | — | — | US | claimed |
| EP-1689721-B1 | AMINOPYRAZOLE DERIVATIVES AS GSK-3 INHIBITORS | PFIZER PROD INC (US) | 2010-07-14 | — | — | EP | disclosed |