Acetic Acid

Acetic Acid

SCHEMBL312459

CC(=O)O.OCl

nearest known ligand 0.00

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetic Acid SCHEMBL29039833 1.00 FFAR3 (0.78)
Acetic Acid SCHEMBL3961679 0.95
Acetic Acid SCHEMBL28339603 0.95
Acetic Acid SCHEMBL1632560 0.95
Acetic Acid SCHEMBL7704933 0.95
Acetic Acid SCHEMBL11881601 0.91
Tetrachloroethylene SCHEMBL27902967 0.91 FFAR3 (0.64)
Acetic Acid SCHEMBL7359120 0.89
Acetic Acid SCHEMBL10553195 0.89
Acetic Acid SCHEMBL6788 0.88 FFAR3 (1.00)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10005780-B2 Production method of imidazole derivatives TAKEDA PHARMACEUTICAL COMPANY (JP) 2018-06-26 US disclosed
US-20160244454-A1 PRODUCTION METHOD OF IMIDAZOLE DERIVATIVES TAKEDA PHARMACEUTICALS CO (JP) 2016-08-25 US disclosed
US-9278938-B2 Production method of imidazole derivatives TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2016-03-08 US disclosed
CN-103608334-B The preparation method of imdazole derivatives TAKEDA PHARMACEUTICAL CO.,LTD. (JP) 2015-12-23 CN disclosed
EP-2721010-B1 PRODUCTION METHOD OF IMIDAZOLE DERIVATIVES TAKEDA PHARMACEUTICAL (JP) 2015-09-09 EP disclosed
EP-2721010-A1 PRODUCTION METHOD OF IMIDAZOLE DERIVATIVES Takeda Pharmaceutical Company Limited (JP) 2014-04-23 EP disclosed
US-20140100373-A1 PRODUCTION METHOD OF IMIDAZOLE DERIVATIVES TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2014-04-10 US disclosed
CN-103608334-A Production method of imidazole derivatives TAKAEDA CHEMICAL IND LTD 2014-02-26 CN disclosed
US-8586762-B2 Process for producing fused imidazole compound, reformatsky reagent in stable form, and process for producing the same TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2013-11-19 US disclosed
WO-2012173280-A1 PRODUCTION METHOD OF IMIDAZOLE DERIVATIVES TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2012-12-20 WO disclosed
US-20120077985-A1 PROCESS FOR PRODUCING FUSED IMIDAZOLE COMPOUND, REFORMATSKY REAGENT IN STABLE FORM, AND PROCESS FOR PRODUCING THE SAME TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2012-03-29 US disclosed
US-8093403-B2 Process for producing fused imidazole compound, reformatsky reagent in stable form, and process for producing the same TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2012-01-10 US disclosed
EP-2275411-A2 Reformatsky Reagent in Stable Form and Process for Producing the Same Takeda Pharmaceutical Company Limited (JP) 2011-01-19 EP disclosed
US-20100105922-A1 PROCESS FOR PRODUCING FUSED IMIDAZOLE COMPOUND, REFORMATSKY REAGENT IN STABLE FORM, AND PROCESS FOR PRODUCING THE SAME TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-04-29 US disclosed
US-7662974-B2 reduction of carboxylic acid ester using metal hydride complexes and metal halides to form compounds such as ethyl (3S)-3-hydroxy-3-{6-[(methylamino)carbonyl]-2-naphthyl}-3-(1-trityl-1H-imidazol-4-yl)propanoate, used as lyase enzyme inhibitors TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-02-16 US disclosed
CN-100531937-C Method of sterilization and electrolytic water ejecting apparatus PERMELEC ELECTRODE LTD (JP) 2009-08-26 CN disclosed
CN-1899975-A Method of sterilization and electrolytic water ejecting apparatus PERMELEC ELECTRODE LTD (JP) 2007-01-24 CN disclosed
US-20050043544-A1 Process for producing fused imidazole compound, reformatsky reagent in stable form, and process for producing the same TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2005-02-24 US disclosed
EP-1471056-A1 PROCESS FOR PRODUCING FUSED IMIDAZOLE COMPOUND, REFORMATSKY REAGENT IN STABLE FORM, AND PROCESS FOR PRODUCING THE SAME Takeda Chemical Industries, Ltd. (JP) 2004-10-27 EP disclosed
US-4767564-A 4-BUTYROLACTONE, ETHYLENE GLYCOL MONOMETHYL ETHER ACETATE; SODIUM HYPOCHLORITE SOLUTION THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE (US) 1988-08-30 US disclosed