Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.47 |
| ▸ | JAK2 | O60674 | 8/20 | 0.36 |
| ▸ | JAK1 | P23458 | 7/20 | 0.36 |
| ▸ | TYK2 | P29597 | 7/20 | 0.36 |
| ▸ | JAK3 | P52333 | 7/20 | 0.36 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.32 |
| ▸ | NEK2 | P51955 | 1/20 | 0.31 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.30 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29930100 | 0.94 | MAP4K1 (0.53) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL29608770 | 0.89 | MAP4K1 (0.47) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL31246458 | 0.88 | MAP4K1 (0.44) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL31246485 | 0.88 | MAP4K1 (0.44) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL29608662 | 0.84 | MAP4K1 (0.43) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22859181 | 0.83 | MAP4K1 (0.47) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL29608845 | 0.82 | MAP4K1 (0.53) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL29609242 | 0.82 | MAP4K1 (0.53) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22858872 | 0.82 | MAP4K1 (0.70) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22858870 | 0.82 | MAP4K1 (0.70) | MAP4K1JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115073474-B | Pyrrolo [2,3-b ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2024-10-18 | — | — | CN | disclosed |