Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.53 |
| ▸ | JAK2 | O60674 | 3/20 | 0.35 |
| ▸ | JAK1 | P23458 | 3/20 | 0.35 |
| ▸ | TYK2 | P29597 | 3/20 | 0.35 |
| ▸ | JAK3 | P52333 | 3/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.32 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.31 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31246478 | 0.94 | MAP4K1 (0.47) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL29609242 | 0.88 | MAP4K1 (0.53) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL29608845 | 0.88 | MAP4K1 (0.53) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL31246488 | 0.86 | MAP4K1 (0.69) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL31246471 | 0.86 | MAP4K1 (0.69) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22858799 | 0.85 | MAP4K1 (0.57) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL31246485 | 0.83 | MAP4K1 (0.44) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL31246458 | 0.83 | MAP4K1 (0.44) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL29608770 | 0.82 | MAP4K1 (0.47) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL28717476 | 0.82 | MAP4K1 (0.56) | MAP4K1JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115073474-A | Pyrrolo [2,3-b ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2022-09-20 | — | — | CN | disclosed |