⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15599294 | 0.83 | NPC1 (0.37) | — | |
| SCHEMBL10297764 | 0.78 | — | — | |
| SCHEMBL10021905 | 0.77 | CCR1 (0.45) | — | |
| SCHEMBL10021910 | 0.77 | NPC1 (0.35) | — | |
| SCHEMBL25036501 | 0.77 | HTR2C (0.32) | — | |
| SCHEMBL14129669 | 0.75 | GRM5 (0.41) | — | |
| SCHEMBL14129670 | 0.75 | GRM5 (0.33) | — | |
| SCHEMBL15599297 | 0.75 | NPC1 (0.54) | — | |
| SCHEMBL754165 | 0.72 | — | — | |
| SCHEMBL4436936 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 4714 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119409918-A | Application of organic framework material in electronic special gas adsorption storage and delivery | 浙江大学 | 2025-02-11 | — | — | CN | claimed |
| CN-117624521-A | Ionic covalent organic framework material, solid phase synthesis method and application thereof | 耀科新材料(苏州)有限公司 | 2024-03-01 | — | — | CN | claimed |
| WO-2024037615-A1 | IONIC COVALENT ORGANIC FRAMEWORK MATERIAL, SOLID-PHASE SYNTHESIS METHOD THEREOF, AND USE THEREOF | 耀科新材料（天津）有限公司 | 2024-02-22 | — | — | WO | claimed |
| US-20230192657-A1 | 1,2,4-TRIAZOLINONE CB1 INHIBITORS | GFB (ABC), LLC | 2023-06-22 | — | — | US | claimed |
| EP-4114838-A1 | 1,2,4-TRIAZOLINONE CB1 INHIBITORS | Goldfinch Bio, Inc. (US) | 2023-01-11 | — | — | EP | claimed |
| CN-114929782-A | Method for producing mixed polyamides, polyimides and polyamideimides by hydrothermal polymerization | 埃克森美孚技术与工程公司 | 2022-08-19 | — | — | CN | claimed |
| US-20170056398-A1 | SUBSTITUTED PYRIDINES AS P2X3 AND P2X2/3 ANTAGONISTS | ROCHE PALO ALTO LLC (US) | 2017-03-02 | — | — | US | claimed |
| US-20160362395-A1 | INDOLE, INDAZOLE AND BENZIMIDAZOLE ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS | ROCHE PALO ALTO LLC (US) | 2016-12-15 | — | — | US | claimed |
| US-9440956-B2 | Indole, indazole and benzimidazole arylamides as P2X3 and P2X2/3 antagonists | ROCHE PALO ALTO LLC (US) | 2016-09-13 | — | — | US | claimed |
| EP-2445889-B1 | NOVEL BENZOXAZOLONE -SUBSTITUTED ARYLAMIDES | HOFFMANN LA ROCHE (CH) | 2016-08-10 | — | — | EP | claimed |
| EP-2445889-A1 | NOVEL OXAZOLONE AND PYRROLIDINONE-SUBSTITUTED ARYLAMIDES | F. Hoffmann-La Roche AG (CH) | 2012-05-02 | — | — | EP | claimed |
| EP-2445897-A1 | NOVEL INDOLE, INDAZOLE AND BENZIMIDAZOLE ARYLAMIDES AS P2X3 AND/OR P2X2/3 ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2012-05-02 | — | — | EP | claimed |
| US-20120083500-A1 | OXAZOLONE AND PYRROLIDINONE-SUBSTITUTED ARYLAMIDES AS P2X3 AND P2X 2/3 ANTAGONISTS | CHEN LI (CN) | 2012-04-05 | — | — | US | claimed |
| US-8093275-B2 | Oxazolone and pyrrolidinone-substituted pryidine amides as P2X3 and P2X2/3 antagonists | ROCHE PALO ALTO LLC (US) | 2012-01-10 | — | — | US | claimed |
| WO-2010149634-A1 | NOVEL INDOLE, INDAZOLE AND BENZIMIDAZOLE ARYLAMIDES AS P2X3 AND/OR P2X2/3 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-12-29 | — | — | WO | claimed |
| WO-2010149541-A1 | NOVEL OXAZOLONE AND PYRROLIDINONE-SUBSTITUTED ARYLAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-12-29 | — | — | WO | claimed |
| US-20100324070-A1 | INDOLE, INDAZOLE AND BENZIMIDAZOLE ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS | DILLON MICHAEL PATRICK | 2010-12-23 | — | — | US | claimed |
| US-20100324069-A1 | OXAZOLONE AND PYRROLIDINONE-SUBSTITUTED ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS | CHEN LI | 2010-12-23 | — | — | US | claimed |
| US-4415566-A | ANTIBIOTICS; BACTERIOSTATS; BACTERICIDES | BOEHRINGER INGELHEIM GMBH (DE) | 1983-11-15 | — | — | US | claimed |
| EP-0022494-B1 | BETA-LACTAM-COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THERAPEUTIC AGENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1983-02-23 | — | — | EP | claimed |