SCHEMBL31258173

SCHEMBL31258173

Clc1ccc(C2C=COCC2)c(Cl)c1

nearest known ligand 0.41

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.41
TSHR P16473 1/20 0.41
AGTR1 P30556 1/20 0.41
HTR2A P28223 1/20 0.41
HTR2C P28335 1/20 0.41
HTR2B P41595 1/20 0.41
MAP3K14 Q99558 1/20 0.38
CNR1 P21554 2/20 0.36
AR P10275 1/20 0.34
CHRNB2 P17787 1/20 0.34
CHRNA4 P43681 1/20 0.34
MAPT P10636 2/20 0.34
ALDH1A1 P00352 1/20 0.34
THRB P10828 1/20 0.34
HTT P42858 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
USP2 O75604 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31258154 0.75 HTR3A (0.35) HTR2AHTR2CHTR2B
SCHEMBL31258197 0.71 SLC6A2 (0.38) NPSR1
SCHEMBL23672520 0.71 GAA (0.47) GAATSHRAGTR1HTR2AHTR2C
SCHEMBL12230871 0.68 TAAR1 (0.48) HTR2AHTR2CHTR2BMAP3K14CHRNB2
SCHEMBL433540 0.68 GAA (0.52) GAATSHRAGTR1HTR2AHTR2C
SCHEMBL7670453 0.67 HTR2A (0.47) GAATSHRAGTR1HTR2AHTR2C
SCHEMBL31258158 0.66 HTR2C (0.39) GAAHTR2AHTR2CHTR2BALDH1A1
SCHEMBL29859210 0.66 GAA (0.39) GAATSHRAGTR1HTR2AHTR2C
SCHEMBL4311498 0.65 HTR2A (0.49) GAATSHRAGTR1HTR2AHTR2C
SCHEMBL1583058 0.65 HTR2A (0.49) GAATSHRAGTR1HTR2AHTR2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119039312-A Method for preparing medical intermediate 3-benzimidazoline coumarin pyranone derivative by catalyzing acid eutectic solvent 南京欣久医药科技有限公司 2024-11-29 CN disclosed