SCHEMBL31258652

SCHEMBL31258652

COc1cc(-n2cccn2)c(-c2ccc3c(N)cnnc3c2)cc1OB(O)O

nearest known ligand 0.39

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
PDE10A Q9Y233 17/20 0.39
LRRK2 Q5S007 1/20 0.37
DHFR P00374 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25261985 0.89 PDE10A (0.38) PDE10ALRRK2DHFR
SCHEMBL26067381 0.88 LRRK2 (0.37) PDE10ALRRK2DHFR
Formic Acid SCHEMBL25300942 0.85 LRRK2 (0.37) PDE10ALRRK2DHFR
SCHEMBL25261130 0.83 LRRK2 (0.36) PDE10ALRRK2DHFR
SCHEMBL25840831 0.82 LRRK2 (0.37) PDE10ALRRK2
SCHEMBL25304207 0.81 DHFR (0.37) PDE10ALRRK2DHFR
SCHEMBL25840716 0.81 LRRK2 (0.34) PDE10ALRRK2
SCHEMBL25840906 0.81 LRRK2 (0.32) PDE10ALRRK2
SCHEMBL26067399 0.81 LRRK2 (0.36) PDE10ALRRK2
SCHEMBL25259035 0.81 LRRK2 (0.33) LRRK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118715231-A Complement factor inhibitors and uses thereof 安尼艾克松股份有限公司 2024-09-27 CN disclosed