Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 6/20 | 0.78 |
| ▸ | LPAR3 | Q9UBY5 | 6/20 | 0.78 |
| ▸ | LPAR2 | Q9HBW0 | 3/20 | 0.58 |
| ▸ | LPAR5 | Q9H1C0 | 3/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.53 |
| ▸ | PRKCG | P05129 | 2/20 | 0.53 |
| ▸ | PRKCB | P05771 | 2/20 | 0.53 |
| ▸ | PRKCA | P17252 | 2/20 | 0.53 |
| ▸ | PRKCH | P24723 | 2/20 | 0.53 |
| ▸ | PRKCI | P41743 | 2/20 | 0.53 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.53 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.53 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.53 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.53 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.53 |
| ▸ | AKT1 | P31749 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL11123292 | 1.00 | LPAR1 (0.78) | LPAR1LPAR3LPAR2LPAR5PRKD3 | |
| Choline SCHEMBL30899083 | 1.00 | LPAR1 (0.78) | LPAR1LPAR3LPAR2LPAR5PRKD3 | |
| Alcohol SCHEMBL28054641 | 0.90 | LPAR3 (0.91) | LPAR1LPAR3LPAR2LPAR5LPAR6 | |
| Choline SCHEMBL28147311 | 0.89 | LPAR1 (0.60) | LPAR1LPAR3LPAR2LPAR5PRKD3 | |
| Choline SCHEMBL28271776 | 0.89 | LPAR1 (0.60) | LPAR1LPAR3LPAR2LPAR5PRKD3 | |
| Choline SCHEMBL28104751 | 0.89 | LPAR1 (0.60) | LPAR1LPAR3LPAR2LPAR5PRKD3 | |
| Alcohol SCHEMBL27915917 | 0.88 | LPAR3 (0.94) | LPAR1LPAR3LPAR2LPAR5LPAR6 | |
| SCHEMBL5055004 | 0.88 | LPAR3 (1.00) | LPAR1LPAR3LPAR2LPAR5LPAR6 | |
| SCHEMBL2814732 | 0.88 | LPAR3 (1.00) | LPAR1LPAR3LPAR2LPAR5LPAR6 | |
| SCHEMBL496845 | 0.88 | LPAR3 (1.00) | LPAR1LPAR3LPAR2LPAR5LPAR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119032086-A | Sulfide-containing ionizable lipids and lipid nanoparticles comprising same | 瑟吉尼克斯有限公司 | 2024-11-26 | — | — | CN | disclosed |