SCHEMBL31268841

SCHEMBL31268841

CNCCOc1ccc(-c2nc3c(OC4(C)CC4)ncnc3n2Cc2cc(Cl)ccn2)c(Cl)c1

nearest known ligand 0.33

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ CNR1 P21554 5/20 0.33
▸ KCNH2 Q12809 2/20 0.33
▸ KDM4E B2RXH2 1/20 0.32
▸ ALDH1A1 P00352 1/20 0.32
▸ LMNA P02545 1/20 0.32
▸ PIK3CD O00329 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31269267 0.98 CNR1 (0.32) CNR1KCNH2KDM4EALDH1A1LMNA
SCHEMBL31268874 0.94 KDM4E (0.32) KCNH2KDM4EALDH1A1LMNAPIK3CD
SCHEMBL31269111 0.92 HRH4 (0.32) KCNH2KDM4EALDH1A1LMNAPIK3CD
SCHEMBL30983885 0.91 CNR1 (0.33) CNR1KCNH2PIK3CD
SCHEMBL31269351 0.91 PIK3CD (0.35) CNR1KCNH2PIK3CD
SCHEMBL31269005 0.90 PDE2A (0.35) CNR1KCNH2PIK3CD
SCHEMBL31268765 0.90 TLR7 (0.37) CNR1KCNH2KDM4EPIK3CD
SCHEMBL30984070 0.89 TLR7 (0.34) CNR1KCNH2KDM4EPIK3CD
SCHEMBL31269346 0.87 PIK3CD (0.34) CNR1KCNH2PIK3CD
SCHEMBL30983807 0.85 PIK3CD (0.35) CNR1KCNH2PIK3CD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4689155-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS Astrazeneca AB (SE) 2026-02-11 — — EP disclosed
WO-2024201368-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS ASTRAZENECA AB (SE) 2024-10-03 — — WO disclosed
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