SCHEMBL31269038

SCHEMBL31269038

Cc1ccnc(Cn2c(-c3ccc(OCCS(C)(=O)=O)cc3Cl)nc3c(OC4(C)CC4)ncnc32)c1

nearest known ligand 0.32

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ PIK3CD O00329 1/20 0.32
▸ KCNH2 Q12809 1/20 0.31
▸ SCN5A Q14524 1/20 0.31
▸ SCN9A Q15858 1/20 0.31
▸ HRH4 Q9H3N8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31269169 0.96 PIK3CD (0.32) PIK3CDKCNH2SCN5ASCN9AHRH4
SCHEMBL31268908 0.91 KCNJ5 (0.33) PIK3CD
SCHEMBL30983456 0.89 PIK3CD (0.35) PIK3CDKCNH2SCN5ASCN9AHRH4
SCHEMBL30984004 0.89 KCNH2 (0.32) PIK3CDKCNH2SCN5ASCN9AHRH4
SCHEMBL31268950 0.89 KCNH2 (0.32) PIK3CDKCNH2SCN5ASCN9AHRH4
SCHEMBL31269061 0.89 MET (0.33) PIK3CDKCNH2SCN5ASCN9AHRH4
SCHEMBL30984043 0.89 TLR7 (0.37) PIK3CDKCNH2SCN5ASCN9AHRH4
SCHEMBL31268935 0.89 PDE2A (0.34) PIK3CDKCNH2SCN5ASCN9AHRH4
SCHEMBL31269189 0.89 HRH4 (0.33) PIK3CDKCNH2SCN5ASCN9AHRH4
SCHEMBL31268874 0.88 KDM4E (0.32) PIK3CDKCNH2SCN5ASCN9AHRH4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4689155-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS Astrazeneca AB (SE) 2026-02-11 — — EP disclosed
WO-2024201368-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS ASTRAZENECA AB (SE) 2024-10-03 — — WO disclosed
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