SCHEMBL31269193

SCHEMBL31269193

Cc1ccnc(Cn2c(-c3ccc(CC(=O)N4CC(N5CCC5)C4)cc3Cl)nc3c(OC4(C)CC4)ncnc32)c1

nearest known ligand 0.36

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ PIK3CD O00329 15/20 0.36
▸ DGAT1 O75907 2/20 0.32
▸ CCR3 P51677 1/20 0.32
▸ KCNH2 Q12809 1/20 0.32
▸ SCN5A Q14524 1/20 0.32
▸ SCN9A Q15858 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31268789 0.93 PIK3CD (0.37) PIK3CDKCNH2SCN5ASCN9A
SCHEMBL31268975 0.91 PIK3CD (0.37) PIK3CDKCNH2SCN5ASCN9A
SCHEMBL31269112 0.90 PIK3CD (0.34) PIK3CDDGAT1KCNH2SCN5ASCN9A
SCHEMBL31268979 0.89 PIK3CD (0.35) PIK3CDDGAT1KCNH2SCN5ASCN9A
SCHEMBL31268900 0.89 PIK3CD (0.35) PIK3CDDGAT1KCNH2SCN5ASCN9A
SCHEMBL31269030 0.89 PIK3CD (0.35) PIK3CDDGAT1KCNH2SCN5ASCN9A
SCHEMBL31269300 0.89 DGAT1 (0.41) PIK3CDDGAT1KCNH2SCN5ASCN9A
SCHEMBL31268868 0.89 PIK3CD (0.39) PIK3CDDGAT1KCNH2SCN5ASCN9A
SCHEMBL31269139 0.89 PIK3CD (0.39) PIK3CDDGAT1KCNH2SCN5ASCN9A
SCHEMBL31269213 0.89 PIK3CD (0.36) PIK3CDDGAT1KCNH2SCN5ASCN9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4689155-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS Astrazeneca AB (SE) 2026-02-11 — — EP disclosed
WO-2024201368-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS ASTRAZENECA AB (SE) 2024-10-03 — — WO disclosed
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