Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21777266 | 0.92 | NR1H2 (0.42) | HPGDKDM4EPKMGPR119RECQL | |
| SCHEMBL21774628 | 0.92 | NR1H2 (0.42) | HPGDKDM4EPKMGPR119RECQL | |
| SCHEMBL21774626 | 0.92 | NR1H2 (0.42) | HPGDKDM4EPKMGPR119RECQL | |
| SCHEMBL21997138 | 0.87 | HPGD (0.47) | HPGDKDM4EPKMGPR119RECQL | |
| SCHEMBL796239 | 0.85 | HPGD (0.53) | HPGDKDM4EPKMGPR119RECQL | |
| SCHEMBL5661309 | 0.84 | MEN1 (0.47) | HPGDEPHX1 | |
| SCHEMBL31303434 | 0.84 | GPR119 (0.46) | HPGDKDM4EPKMGPR119RECQL | |
| SCHEMBL14392667 | 0.84 | MEN1 (0.47) | HPGDEPHX1 | |
| SCHEMBL14392764 | 0.84 | MEN1 (0.47) | HPGDEPHX1 | |
| SCHEMBL15103176 | 0.83 | HPGD (0.48) | HPGDKDM4EPKMGPR119RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4727552-A2 | PASSIVE PERMEABLE PCSK9 ANTAGONIST COMPOUNDS | Merck Sharp & Dohme LLC (US) | 2026-04-22 | — | — | EP | disclosed |
| WO-2024259310-A2 | PASSIVE PERMEABLE PCSK9 ANTAGONIST COMPOUNDS | MERCK SHARP & DOHME LLC (US) | 2024-12-19 | — | — | WO | disclosed |