SCHEMBL31279366

SCHEMBL31279366

O=C1CCN(N2Cc3cc(CN4CC=C(c5ccoc5)CC4)ccc3C2=O)C(=O)N1

nearest known ligand 0.46

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
IKZF1 Q13422 2/20 0.46
PARP1 P09874 5/20 0.41
DRD4 P21917 2/20 0.41
DRD2 P14416 1/20 0.41
IKZF2 Q9UKS7 2/20 0.36
KDM4E B2RXH2 3/20 0.34
GAA P10253 3/20 0.34
MAPT P10636 3/20 0.34
HTR1A P08908 1/20 0.33
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
ATM Q13315 1/20 0.33
NAMPT P43490 1/20 0.32
MAPK1 P28482 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31279744 0.86 PARP1 (0.42) IKZF1PARP1DRD4DRD2IKZF2
SCHEMBL31279777 0.84 IKZF1 (0.46) IKZF1PARP1DRD4DRD2IKZF2
SCHEMBL31279560 0.84 IKZF1 (0.44) IKZF1PARP1DRD4DRD2IKZF2
SCHEMBL31279098 0.83 IKZF1 (0.45) IKZF1PARP1DRD4DRD2IKZF2
SCHEMBL31279785 0.82 IKZF1 (0.46) IKZF1PARP1DRD4DRD2IKZF2
SCHEMBL31338354 0.81 IKZF1 (0.71) IKZF1IKZF2
SCHEMBL31279146 0.81 IKZF1 (0.44) IKZF1PARP1DRD4DRD2IKZF2
SCHEMBL31279902 0.80 IKZF1 (0.46) IKZF1PARP1DRD4DRD2IKZF2
SCHEMBL31279514 0.80 IKZF1 (0.42) IKZF1PARP1DRD4DRD2IKZF2
SCHEMBL31279745 0.79 IKZF2 (0.46) IKZF1PARP1DRD4DRD2IKZF2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4722207-A1 OXOISOINDOLINYL-SUBSTITUTED TETRAHYDROPYRIMIDINEDIONE DERIVATIVE AND USE THEREOF Gluetacs Therapeutics (Shanghai) Co., Ltd. (CN) 2026-04-08 EP claimed
CN-119451952-A Oxo-isoindolinyl substituted tetrahydropyrimidinedione derivative and application thereof 标新生物医药科技(上海)有限公司 2025-02-14 CN claimed
WO-2024245444-A1 OXOISOINDOLINYL-SUBSTITUTED TETRAHYDROPYRIMIDINEDIONE DERIVATIVE AND USE THEREOF 标新生物医药科技(上海)有限公司 2024-12-05 WO claimed
EP-4722207-A1 OXOISOINDOLINYL-SUBSTITUTED TETRAHYDROPYRIMIDINEDIONE DERIVATIVE AND USE THEREOF Gluetacs Therapeutics (Shanghai) Co., Ltd. (CN) 2026-04-08 EP disclosed
CN-119451952-A Oxo-isoindolinyl substituted tetrahydropyrimidinedione derivative and application thereof 标新生物医药科技(上海)有限公司 2025-02-14 CN disclosed
WO-2024245444-A1 OXOISOINDOLINYL-SUBSTITUTED TETRAHYDROPYRIMIDINEDIONE DERIVATIVE AND USE THEREOF 标新生物医药科技(上海)有限公司 2024-12-05 WO disclosed