Sugi Predict

Sugi Predict / Compounds / SCHEMBL31281986

SCHEMBL31281986

SCHEMBL31281986

Cn1c(=O)n(C2CCC(=O)NC2=O)c2cccc(CN3CCC(OC4CCC(NC(=O)O)CC4)CC3)c21

nearest known ligand 0.46

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ DDB1 Q16531 14/20 0.46
▸ CRBN Q96SW2 14/20 0.46
▸ IKZF2 Q9UKS7 1/20 0.35
▸ SIGMAR1 Q99720 2/20 0.34
▸ IRAK4 Q9NWZ3 1/20 0.34
▸ OPRM1 P35372 2/20 0.33
▸ OPRL1 P41146 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23832693 0.89 CRBN (0.48) DDB1CRBNIKZF2IRAK4
SCHEMBL23807915 0.86 CRBN (0.48) DDB1CRBNIKZF2IRAK4OPRM1
SCHEMBL21996979 0.86 CRBN (0.48) DDB1CRBNIKZF2IRAK4OPRM1
SCHEMBL21996871 0.86 CRBN (0.51) DDB1CRBNIKZF2
SCHEMBL23842432 0.86 DRD2 (0.43) DDB1CRBNIRAK4
SCHEMBL23832614 0.86 DRD2 (0.43) DDB1CRBNIRAK4
SCHEMBL27058468 0.86 DRD2 (0.43) DDB1CRBNIRAK4
Hydrochloric Acid SCHEMBL21997496 0.85 CRBN (0.50) DDB1CRBNIKZF2
SCHEMBL21997604 0.84 DDB1 (0.45) DDB1CRBN
SCHEMBL31281949 0.83 DDB1 (0.56) DDB1CRBNIKZF2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4731309-A1 KRAS PROTEOLYSIS TARGETING CHIMERAS Paq Therapeutics Inc. (US) 2026-04-29 — — EP disclosed
WO-2024263586-A1 KRAS PROTEOLYSIS TARGETING CHIMERAS PAQ Therapeutics Inc. (US) 2024-12-26 — — WO disclosed