Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2770208 | 0.92 | GPR119 (0.61) | GPR119HPGDRECQLEPHX1USP2 | |
| SCHEMBL24607647 | 0.89 | GPR119 (0.54) | GPR119HPGDRECQLEPHX1USP2 | |
| SCHEMBL1199550 | 0.87 | HPGD (0.58) | GPR119HPGDRECQLEPHX1USP2 | |
| SCHEMBL14634494 | 0.86 | GPR119 (0.56) | GPR119HPGDRECQLEPHX1USP2 | |
| SCHEMBL14634495 | 0.86 | GPR119 (0.56) | GPR119HPGDRECQLEPHX1USP2 | |
| SCHEMBL21456062 | 0.85 | HPGD (0.58) | GPR119HPGDRECQLEPHX1USP2 | |
| SCHEMBL13128796 | 0.84 | GPR119 (0.54) | GPR119HPGDRECQLEPHX1USP2 | |
| SCHEMBL24582050 | 0.84 | GPR119 (0.57) | GPR119HPGDRECQLEPHX1USP2 | |
| SCHEMBL2773515 | 0.84 | EPHX1 (0.61) | GPR119HPGDRECQLEPHX1USP2 | |
| SCHEMBL31543231 | 0.84 | GPR119 (0.54) | GPR119HPGDRECQLEPHX1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4731309-A1 | KRAS PROTEOLYSIS TARGETING CHIMERAS | Paq Therapeutics Inc. (US) | 2026-04-29 | — | — | EP | disclosed |
| WO-2024263586-A1 | KRAS PROTEOLYSIS TARGETING CHIMERAS | PAQ Therapeutics Inc. (US) | 2024-12-26 | — | — | WO | disclosed |