Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 11/20 | 0.55 |
| ▸ | DRD2 | P14416 | 4/20 | 0.45 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.42 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3001403 | 0.70 | SIGMAR1 (0.61) | SIGMAR1 | |
| SCHEMBL16836026 | 0.67 | AVPR1A (0.52) | SIGMAR1ADRA2A | |
| SCHEMBL3006616 | 0.67 | SIGMAR1 (0.60) | SIGMAR1 | |
| SCHEMBL31283053 | 0.66 | OPRL1 (0.46) | CYP3A4HSD17B10 | |
| SCHEMBL2517838 | 0.66 | SIGMAR1 (0.54) | SIGMAR1ADRA2A | |
| SCHEMBL16836045 | 0.66 | SIGMAR1 (0.56) | SIGMAR1ADRA2A | |
| SCHEMBL3212649 | 0.65 | OPRL1 (0.58) | SIGMAR1CYP3A4HSD17B10 | |
| SCHEMBL16835994 | 0.65 | SIGMAR1 (0.67) | SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL1966477 | 0.65 | SIGMAR1 (0.61) | SIGMAR1DRD2CYP3A4HSD17B10 | |
| SCHEMBL18563358 | 0.65 | SIGMAR1 (0.61) | SIGMAR1DRD2CYP3A4HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4705293-A1 | SPIRO-HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | Amgen Inc. (US) | 2026-03-11 | — | — | EP | disclosed |
| WO-2024229317-A1 | SPIRO-HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | AMGEN INC. (US) | 2024-11-07 | — | — | WO | disclosed |