Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | FPR2 | P25090 | 4/20 | 0.34 |
| ▸ | PROKR1 | Q8TCW9 | 4/20 | 0.34 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3126426 | 0.86 | HCRTR1 (0.42) | FFAR4PTGS1PTGS2FPR2PROKR1 | |
| SCHEMBL2296925 | 0.84 | GRIN1 (0.39) | FFAR4PTGS1PTGS2SLC6A3SLC6A2 | |
| SCHEMBL20780665 | 0.84 | PTGS1 (0.47) | FFAR4PTGS1PTGS2FPR2PROKR1 | |
| SCHEMBL8251445 | 0.79 | FFAR4 (0.38) | FFAR4PTGS1PTGS2FPR2PROKR1 | |
| SCHEMBL3126765 | 0.79 | SLC6A2 (0.53) | SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL2300752 | 0.79 | SLC6A4 (0.45) | PTGS1PTGS2FPR2PROKR1SLC6A3 | |
| SCHEMBL169750 | 0.77 | SYK (0.44) | FFAR4PTGS1PTGS2HRH3 | |
| SCHEMBL12330286 | 0.77 | IDO1 (0.39) | FFAR4PTGS1PTGS2SLC6A3MRGPRX4 | |
| SCHEMBL2297195 | 0.76 | SLC6A4 (0.45) | SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL2299212 | 0.76 | SLC6A2 (0.45) | FPR2PROKR1SLC6A3SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |