Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 11/20 | 0.53 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | GRK6 | P43250 | 3/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3129771 | 1.00 | NTRK1 (0.53) | NTRK1NUAK1KCNH2GRK6IGF1R | |
| SCHEMBL3124443 | 0.89 | NTRK1 (0.51) | NTRK1NUAK1KCNH2PLK4JAK3 | |
| SCHEMBL3124459 | 0.89 | NTRK1 (0.51) | NTRK1NUAK1KCNH2PLK4JAK3 | |
| SCHEMBL3127072 | 0.84 | NUAK1 (0.68) | NTRK1NUAK1IGF1R | |
| SCHEMBL3127054 | 0.84 | NUAK1 (0.68) | NTRK1NUAK1IGF1R | |
| SCHEMBL3137082 | 0.80 | KCNH2 (0.54) | NTRK1KCNH2PLK4JAK3JAK2 | |
| SCHEMBL3137061 | 0.80 | KCNH2 (0.54) | NTRK1KCNH2PLK4JAK3JAK2 | |
| SCHEMBL3126595 | 0.75 | NUAK1 (0.56) | NTRK1NUAK1KCNH2JAK3JAK2 | |
| SCHEMBL3126574 | 0.75 | NUAK1 (0.56) | NTRK1NUAK1KCNH2JAK3JAK2 | |
| SCHEMBL3132402 | 0.74 | NTRK1 (0.46) | NTRK1KCNH2JAK3JAK2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853602-B1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2010-07-14 | — | — | EP | disclosed |