Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | STS | P08842 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | CNR1 | P21554 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3129810 | 1.00 | ALDH1A1 (0.47) | ALDH1A1MEN1KMT2AATMNPC1 | |
| SCHEMBL925279 | 1.00 | ALDH1A1 (0.47) | ALDH1A1MEN1KMT2AATMNPC1 | |
| SCHEMBL925410 | 1.00 | ALDH1A1 (0.47) | ALDH1A1MEN1KMT2AATMNPC1 | |
| SCHEMBL925281 | 1.00 | ALDH1A1 (0.47) | ALDH1A1MEN1KMT2AATMNPC1 | |
| SCHEMBL925541 | 0.96 | MEN1 (0.44) | ALDH1A1MEN1KMT2AATMNPC1 | |
| SCHEMBL27809198 | 0.96 | MEN1 (0.44) | ALDH1A1MEN1KMT2AATMNPC1 | |
| SCHEMBL925540 | 0.96 | MEN1 (0.44) | ALDH1A1MEN1KMT2AATMNPC1 | |
| SCHEMBL925638 | 0.90 | SLC6A2 (0.49) | ALDH1A1MEN1KMT2ANPC1STS | |
| SCHEMBL925639 | 0.90 | SLC6A2 (0.49) | ALDH1A1MEN1KMT2ANPC1STS | |
| SCHEMBL21713147 | 0.89 | KLK7 (0.46) | ALDH1A1MEN1KMT2ANPC1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170863-A2 | PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2010-04-07 | — | — | EP | disclosed |
| WO-2009006567-A2 | PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2009-01-08 | — | — | WO | disclosed |