Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.33 |
| ▸ | BBOX1 | O75936 | 4/20 | 0.56 |
| ▸ | EHMT2 | Q96KQ7 | 4/20 | 0.56 |
| ▸ | EHMT1 | Q9H9B1 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 4/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | CA3 | P07451 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9069066 | 1.00 | BBOX1 (0.56) | BBOX1EHMT2EHMT1ALDH1A1MAOA | |
| Bromide SCHEMBL9069068 | 1.00 | BBOX1 (0.56) | BBOX1EHMT2EHMT1ALDH1A1MAOA | |
| SCHEMBL150725 | 0.96 | BBOX1 (0.60) | BBOX1EHMT2EHMT1ALDH1A1MAOA | |
| Hydrochloric Acid SCHEMBL3629169 | 0.92 | BBOX1 (0.56) | BBOX1EHMT2EHMT1ALDH1A1MAOA | |
| SCHEMBL6477690 | 0.92 | BBOX1 (0.56) | BBOX1EHMT2EHMT1ALDH1A1MAOA | |
| Hydrochloric Acid SCHEMBL30039649 | 0.92 | BBOX1 (0.56) | BBOX1EHMT2EHMT1ALDH1A1MAOA | |
| Phosphine SCHEMBL14917741 | 0.92 | BBOX1 (0.56) | BBOX1EHMT2EHMT1ALDH1A1MAOA | |
| Hydrochloric Acid SCHEMBL1157944 | 0.92 | BBOX1 (0.56) | BBOX1EHMT2EHMT1ALDH1A1MAOA | |
| Hydrochloric Acid SCHEMBL10525049 | 0.89 | BBOX1 (0.53) | BBOX1EHMT2EHMT1ALDH1A1MAOA | |
| Hydrochloric Acid SCHEMBL10533844 | 0.89 | BBOX1 (0.53) | BBOX1EHMT2EHMT1ALDH1A1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025002030-A1 | SARM1 ENZYME ACTIVITY INHIBITOR AND USE THEREOF | 科辉智药(深圳)新药研究中心有限公司 | 2025-01-02 | — | — | WO | disclosed |