BBOX1

Gamma-butyrobetaine dioxygenase · O75936 · BBOX1 on Sugi Atlas →

19,739 patent compounds predicted against BBOX1, 10,675 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL233637	0.64	11/20
Glutarate (SCHEMBL104188)	0.58	11/20
Adipic Acid (SCHEMBL106656)	0.58	10/20
Butyric Acid (SCHEMBL143567)	0.56	10/20
Succinic Acid (SCHEMBL105515)	0.55	10/20
Butyric Acid (SCHEMBL144703)	0.55	10/20
Levulinic Acid (SCHEMBL357248)	0.46	10/20
Levulinic Acid (SCHEMBL357904)	0.39	10/20
SCHEMBL362973	0.53	9/20
Propionic Acid (SCHEMBL146195)	0.50	9/20
Choline (SCHEMBL147729)	0.45	9/20
SCHEMBL170245	0.41	9/20
Citric Acid (SCHEMBL36781)	0.35	9/20
SCHEMBL465409	0.61	8/20
Valeric Acid (SCHEMBL145154)	0.61	8/20
Butyric Acid (SCHEMBL141251)	0.56	8/20
Butyric Acid (SCHEMBL143249)	0.55	8/20
Propionic Acid (SCHEMBL142732)	0.52	8/20
Glutarate (SCHEMBL104190)	0.50	8/20
Butyric Acid (SCHEMBL109152)	0.50	8/20

Clinical trials — most relevant to BBOX1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Acute Regulation of Intestinal and Hepatic Lipoprotein Production by Glucagon	PHASE4	COMPLETED
Effect of Sevoflurane and Desflurane on Heme Oxygenase-1 Expression in Elective Cholecystectomy	PHASE4	WITHDRAWN
Randomized Controlled Trial of Silymarin in Asthma	PHASE2/PHASE3	WITHDRAWN
Broccoli Sprout Extracts Trial to See if NRF2 is Enhanced by Sulforaphane Treatment in Patients With COPD	PHASE2	COMPLETED
Treatment Study of Carnosine Versus Placebo in Gulf War Illness (GWI)	PHASE2	COMPLETED
A Prevention Trial in Subjects at High Risk for Breast Cancer	PHASE2	COMPLETED
Safety Study of High Doses of Zinc in ALS Patients	PHASE1/PHASE2	COMPLETED
Forced Oscillometry in Infants With Bronchopulmonary Dysplasia	nan	RECRUITING
Relationship Between Heme Oxygenase 1 Enzyme Level and Coronary SYNTAX Score	nan	COMPLETED
Efficacy of Essential Phospholipid Versus Betaine HCL/L-Glutamic Acid in MAFLD	nan	NOT_YET_RECRUITING
Genetic Determinants of Congenital Heart Disease Outcomes	nan	COMPLETED
A Feasibility Study: Assessing Photobiomodulation in Myalgic Encephalomyelitis	nan	UNKNOWN
Gene-by-Smoking Interactions and Risk of Atherosclerosis - Ancillary to ARIC	nan	COMPLETED
Egg Intake, Metabolic Outcomes and Choline Levels	nan	RECRUITING
Pharmacogenetic Determinants Of Treatment Response In Children	nan	RECRUITING
EPICO: (Study for the Pro-resolution of Chronic Inflammation in Obesity. Original Acronym From Spanish)	nan	UNKNOWN
In Vivo Assessment of Histamine Pharmacodynamics	nan	WITHDRAWN
The Effect of Broccoli Sprouts as a Nutritional Supplement in the Prevention of Cardiovascular Disease	nan	COMPLETED
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA	nan	RECRUITING
Potential Synergistic Effect of Combined Blood Flow Restriction Training and Betaine Supplementation on Skeletal Muscle	nan	COMPLETED
Mild Intermittent Hypoxia and Its Multipronged Effect on Sleep Apnea	nan	RECRUITING
Plant-based Diets and Body Weight and Selected Metabolic Parameters Management in Obese Patients.	nan	COMPLETED
Impact Of Choline in Patients With NAFLD	nan	UNKNOWN
Role of Metabolic Enzymes in Non-Melanoma Skin Cancer	nan	COMPLETED
The Effect of Raising Ketones Directly With MCT Oil on Inflammation in Healthy Young Adults	nan	COMPLETED
Targeting Oxidative Stress to Prevent Vascular and Skeletal Muscle Dysfunction During Disuse	nan	ACTIVE_NOT_RECRUITING
Cell Signaling and Resistance to Oxidative Stress: Effects of Aging and Exercise	nan	COMPLETED
Molecular Epidemiology of Dioxin-Related Illness in Seveso	nan	COMPLETED
Dietary and Genetic Factors in Asthma & Chronic Bronchitis in a Cohort of Chinese Singaporeans	nan	COMPLETED
Prediction of Atherosclerotic Plaque Progression	nan	ACTIVE_NOT_RECRUITING

Related proteins — ESM-2 sequence neighbours (a BBOX1 binder may also engage these)

Protein	Name	Similarity
Q5R5D8	—	1.000	Q5R5D8 →
Q924Y0	—	1.000	Q924Y0 →
Q9QZU7	—	1.000	Q9QZU7 →
A5DCB6	—	0.988	A5DCB6 →
Q19000	—	0.987	Q19000 →
Q9LIG0	—	0.976	Q9LIG0 →
Q92178	—	0.975	Q92178 →
A2RTX5	—	0.975	A2RTX5 →
Q5R5P3	—	0.975	Q5R5P3 →
Q15031	—	0.974	Q15031 →
D9IVE5	—	0.973	D9IVE5 →
Q8BLY2	—	0.973	Q8BLY2 →
P11035	—	0.973	P11035 →
P11605	—	0.973	P11605 →
IARS2	Isoleucine--tRNA ligase, mitochondrial	0.973	landscape →
CAPN9	Calpain-9	0.973	landscape →
P11725	—	0.973	P11725 →
Q54EF2	—	0.972	Q54EF2 →
P11832	—	0.972	P11832 →
Q68EH8	—	0.972	Q68EH8 →
B3DLB3	—	0.972	B3DLB3 →
Q96I59	—	0.972	Q96I59 →
Q4R8B6	—	0.972	Q4R8B6 →
Q16P90	—	0.972	Q16P90 →
Q0V9S0	—	0.971	Q0V9S0 →
Q95K79	—	0.971	Q95K79 →
Q96BT7	—	0.971	Q96BT7 →
P00927	—	0.971	P00927 →
E2JA28	—	0.971	E2JA28 →
Q9NWZ5	—	0.971	Q9NWZ5 →