SCHEMBL31301412

SCHEMBL31301412

CC(C)(C)[Si](C)(C)Oc1cc(Cl)ccc1NC(=O)c1cncc(-c2ccc(C(F)(F)F)cc2)n1

nearest known ligand 0.47

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
SCN10A Q9Y5Y9 11/20 0.47
SCN2A Q99250 9/20 0.47
LIPE Q05469 3/20 0.39
THRB P10828 1/20 0.39
MAPT P10636 1/20 0.38
ABL1 P00519 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31301498 0.88 SCN10A (0.56) SCN10ASCN2ALIPETHRBMAPT
SCHEMBL31301391 0.86 SCN10A (0.52) SCN10ASCN2ALIPETHRBABL1
SCHEMBL31301408 0.83 SCN10A (0.56) SCN10ASCN2ALIPETHRBMAPT
SCHEMBL31301428 0.77 SCN10A (0.63) SCN10ASCN2AMAPTABL1
SCHEMBL31301566 0.77 SCN10A (0.52) SCN10ASCN2AMAPT
SCHEMBL31301529 0.76 SCN10A (0.63) SCN10ASCN2AMAPTABL1
SCHEMBL31301502 0.74 SCN10A (0.56) SCN10ASCN2AABL1
SCHEMBL31301416 0.72 SCN10A (0.52) SCN10ASCN2AMAPT
SCHEMBL31301532 0.71 SCN10A (0.52) SCN10ASCN2ATHRBMAPT
SCHEMBL31301471 0.71 SCN10A (0.50) SCN10ASCN2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4727549-A2 PLASMODIUM FALCIPARUM BLOOD STAGE INHIBITORS University of Georgia Research Foundation, Inc. (US) 2026-04-22 EP disclosed
US-20260097046-A1 PLASMODIUM FALCIPARUM BLOOD STAGE INHIBITORS UNIV GEORGIA (US) 2026-04-09 US disclosed
WO-2024258900-A2 PLASMODIUM FALCIPARUM BLOOD STAGE INHIBITORS UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) 2024-12-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260097046-A1 PLASMODIUM FALCIPARUM BLOOD STAGE INHIBITORS SUB1, PFN1, HCCS SCN10A 3171/4885SCN2A 2686/4885LIPE 4608/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.