Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 20/20 | 0.73 |
| ▸ | CXCR1 | P25024 | 19/20 | 0.73 |
| ▸ | CCR7 | P32248 | 4/20 | 0.73 |
| ▸ | CCR6 | P51684 | 2/20 | 0.73 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3131139 | 1.00 | CXCR2 (0.73) | CXCR2CXCR1CCR7CCR6CXCR3 | |
| Navarixin Anhydrous SCHEMBL184744 | 0.84 | CXCR2 (1.00) | CXCR2CXCR1CCR7CCR6 | |
| Navarixin Anhydrous SCHEMBL12262719 | 0.84 | CXCR2 (1.00) | CXCR2CXCR1CCR7CCR6 | |
| Navarixin Anhydrous SCHEMBL1446663 | 0.84 | CXCR2 (1.00) | CXCR2CXCR1CCR7CCR6 | |
| Navarixin Anhydrous SCHEMBL2024684 | 0.83 | CXCR2 (0.98) | CXCR2CXCR1CCR7CCR6 | |
| Navarixin Anhydrous SCHEMBL2024683 | 0.83 | CXCR2 (0.98) | CXCR2CXCR1CCR7CCR6 | |
| SCHEMBL12262645 | 0.81 | CXCR2 (1.00) | CXCR2CXCR1CCR7CCR6CXCR3 | |
| SCHEMBL12262705 | 0.81 | CXCR2 (1.00) | CXCR2CXCR1CCR7CCR6CXCR3 | |
| SCHEMBL12262704 | 0.81 | CXCR2 (1.00) | CXCR2CXCR1CCR7CCR6CXCR3 | |
| SCHEMBL14865057 | 0.80 | CXCR2 (0.82) | CXCR2CXCR1CCR7CCR6CXCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2168956-B8 | Synthesis of 2-Hydroxy-N,N-Dimethyl-3-[[2-[1(r) - (5-Methyl-2-Furanyl) Propyl] -3, 4-Dioxo-1-Cyclobuten-1-Yl]amino] Benzamide | MERCK SHARP & DOHME (US) | 2013-05-01 | — | — | EP | disclosed |
| EP-2168956-B1 | Synthesis of 2-Hydroxy-N,N-Dimethyl-3-[[2-[1(r) - (5-Methyl-2-Furanyl) Propyl] -3, 4-Dioxo-1-Cyclobuten-1-Yl]amino] Benzamide | MERCK SHARP & DOHME (US) | 2013-03-20 | — | — | EP | disclosed |
| EP-2168956-A3 | Synthesis of 2-Hydroxy-N,N-Dimethyl-3-[[2-[1(r) - (5-Methyl-2-Furanyl) Propyl] -3, 4-Dioxo-1-Cyclobuten-1-Yl]amino] Benzamide | SCHERING CORPORATION (US) | 2010-07-14 | — | — | EP | disclosed |
| EP-2168956-A2 | Synthesis of 2-Hydroxy-N,N-Dimethyl-3-[[2-[1(r) - (5-Methyl-2-Furanyl) Propyl] -3, 4-Dioxo-1-Cyclobuten-1-Yl]amino] Benzamide | SCHERING CORPORATION (US) | 2010-03-31 | — | — | EP | disclosed |