Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 13/20 | 0.73 |
| ▸ | MAPK14 | Q16539 | 13/20 | 0.73 |
| ▸ | KDR | P35968 | 10/20 | 0.73 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | TEK | Q02763 | 3/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | FYN | P06241 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | LYN | P07948 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2943932 | 0.84 | LCK (1.00) | LCKMAPK14KDRNPC1RAB9A | |
| SCHEMBL2952129 | 0.83 | LCK (1.00) | LCKMAPK14KDRNPC1RAB9A | |
| SCHEMBL3131379 | 0.82 | LCK (0.81) | LCKMAPK14KDRNPC1RAB9A | |
| SCHEMBL2941869 | 0.81 | LCK (1.00) | LCKMAPK14KDRNPC1RAB9A | |
| SCHEMBL5498378 | 0.77 | LCK (0.70) | LCKMAPK14KDRTEKJAK3 | |
| SCHEMBL2944014 | 0.71 | LCK (0.77) | LCKMAPK14KDRTEKJAK3 | |
| SCHEMBL19496537 | 0.70 | LCK (0.59) | LCKMAPK14KDRNPC1RAB9A | |
| SCHEMBL4721744 | 0.70 | LCK (0.81) | LCKMAPK14KDRNPC1RAB9A | |
| SCHEMBL18707357 | 0.69 | RAB9A (1.00) | NPC1RAB9ASMN1; SMN2TP53POLB | |
| SCHEMBL30962860 | 0.69 | LCK (0.73) | LCKMAPK14KDRTEKBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7754717-B2 | Bis-aryl amide compounds and methods of use | AMGEN INC. (US) | 2010-07-13 | — | — | US | claimed |