SCHEMBL31318543

SCHEMBL31318543

O=C(c1cc(Br)c(O)c(Br)c1)N1CC2(CC2)Oc2ccncc21

nearest known ligand 0.65

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
SLC22A12 Q96S37 5/20 0.65
SLC22A6 Q4U2R8 1/20 0.65
SLC22A8 Q8TCC7 1/20 0.65
KCNH2 Q12809 1/20 0.31
STAT3 P40763 1/20 0.31
KMT2A Q03164 2/20 0.31
MEN1 O00255 1/20 0.31
TTR P02766 1/20 0.31
CCNC P24863 1/20 0.30
CDK8 P49336 1/20 0.30
HASPIN Q8TF76 1/20 0.30
CDK19 Q9BWU1 1/20 0.30
POLB P06746 1/20 0.30
HSD17B10 Q99714 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31318529 0.93 SLC22A12 (0.57) SLC22A12SLC22A6SLC22A8
SCHEMBL31318505 0.87 SLC22A6 (0.50) SLC22A12SLC22A6SLC22A8KCNH2KMT2A
SCHEMBL1191241 0.87 SLC22A12 (0.65) SLC22A12SLC22A6SLC22A8KCNH2STAT3
SCHEMBL31318506 0.87 SLC22A12 (0.48) SLC22A12SLC22A6SLC22A8
SCHEMBL31318557 0.87 SLC22A12 (0.48) SLC22A12SLC22A6SLC22A8
SCHEMBL31318523 0.84 SLC22A12 (0.44) SLC22A12SLC22A6SLC22A8KMT2AMEN1
SCHEMBL31318541 0.83 SLC22A12 (0.46) SLC22A12SLC22A6SLC22A8KMT2AMEN1
SCHEMBL31318515 0.82 SLC22A12 (0.44) SLC22A12SLC22A6SLC22A8
Epaminurad SCHEMBL1191165 0.79 SLC22A12 (1.00) SLC22A12SLC22A6SLC22A8KCNH2STAT3
SCHEMBL31318558 0.79 SLC22A6 (0.41) SLC22A12SLC22A6SLC22A8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119059989-A URAT1 inhibitor, preparation method and application thereof 中国药科大学 2024-12-03 CN disclosed