Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 20/20 | 0.68 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | RAF1 | P04049 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27243298 | 1.00 | KRAS (0.68) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL25400992 | 0.92 | KRAS (0.70) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL30537095 | 0.92 | KRAS (0.70) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL30779000 | 0.92 | KRAS (0.59) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL27243327 | 0.92 | KRAS (0.59) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL31323332 | 0.91 | KRAS (0.57) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL25435539 | 0.91 | KRAS (0.57) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL31749021 | 0.91 | KRAS (0.62) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL30758934 | 0.90 | KRAS (0.62) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL30810155 | 0.90 | KRAS (0.69) | KRASMAPK3MAPK1RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4735453-A1 | KRAS MODULATING COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2026-05-06 | — | — | EP | disclosed |
| US-20250059208-A1 | KRAS MODULATING COMPOUNDS | GILEAD SCIENCES, INC. | 2025-02-20 | — | — | US | disclosed |
| WO-2025006704-A1 | KRAS MODULATING COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2025-01-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250059208-A1 | KRAS MODULATING COMPOUNDS | KRAS, NRAS, HRAS | KRAS 1/4885MAPK3 251/4885MAPK1 359/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.