Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 12/20 | 0.66 |
| ▸ | CRBN | Q96SW2 | 12/20 | 0.66 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25024461 | 0.94 | DDB1 (0.62) | DDB1CRBNGPR119NAMPT | |
| SCHEMBL31323391 | 0.94 | DDB1 (0.65) | DDB1CRBNGPR119 | |
| SCHEMBL30120110 | 0.93 | DDB1 (0.74) | DDB1CRBNGPR119NAMPT | |
| SCHEMBL20595405 | 0.93 | DDB1 (0.74) | DDB1CRBNGPR119NAMPT | |
| SCHEMBL20595430 | 0.93 | DDB1 (0.74) | DDB1CRBNGPR119NAMPT | |
| SCHEMBL29554651 | 0.90 | DDB1 (0.68) | DDB1CRBNGPR119 | |
| SCHEMBL30817363 | 0.90 | DDB1 (0.69) | DDB1CRBNGPR119NAMPT | |
| SCHEMBL31323592 | 0.89 | DDB1 (0.65) | DDB1CRBNGPR119NAMPT | |
| SCHEMBL23783213 | 0.88 | DDB1 (0.67) | DDB1CRBNGPR119NAMPT | |
| SCHEMBL25845750 | 0.88 | DDB1 (0.65) | DDB1CRBNGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4735452-A2 | HETEROBIFUNCTIONAL COMPOUNDS FOR THE DEGRADATION OF KRAS PROTEIN | Merck Patent GmbH (DE) | 2026-05-06 | — | — | EP | disclosed |
| WO-2025006753-A2 | HETEROBIFUNCTIONAL COMPOUNDS FOR THE DEGRADATION OF KRAS PROTEIN | MERCK PATENT GMBH (DE) | 2025-01-02 | — | — | WO | disclosed |