Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 11/20 | 0.74 |
| ▸ | CRBN | Q96SW2 | 11/20 | 0.74 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.52 |
| ▸ | NAMPT | P43490 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20595405 | 1.00 | DDB1 (0.74) | DDB1CRBNGPR119NAMPTMAPT | |
| SCHEMBL20595430 | 1.00 | DDB1 (0.74) | DDB1CRBNGPR119NAMPTMAPT | |
| SCHEMBL30817363 | 0.96 | DDB1 (0.69) | DDB1CRBNGPR119NAMPTMAPT | |
| SCHEMBL29554651 | 0.95 | DDB1 (0.68) | DDB1CRBNGPR119ALDH1A1 | |
| SCHEMBL24125836 | 0.94 | DDB1 (0.69) | DDB1CRBNGPR119NAMPTALDH1A1 | |
| SCHEMBL31323735 | 0.93 | DDB1 (0.66) | DDB1CRBNGPR119NAMPT | |
| SCHEMBL23783213 | 0.92 | DDB1 (0.67) | DDB1CRBNGPR119NAMPT | |
| SCHEMBL25845750 | 0.92 | DDB1 (0.65) | DDB1CRBNGPR119ALDH1A1 | |
| SCHEMBL29942918 | 0.92 | DDB1 (0.64) | DDB1CRBNGPR119NAMPTMAPT | |
| SCHEMBL29199173 | 0.92 | DDB1 (0.64) | DDB1CRBNGPR119NAMPTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4351583-A1 | THERAPEUTICS FOR THE DEGRADATION OF MUTANT BRAF | C4 Therapeutics, Inc. (US) | 2024-04-17 | — | — | EP | disclosed |
| EP-4168407-A1 | BRAF DEGRADERS | C4 Therapeutics, Inc. (US) | 2023-04-26 | — | — | EP | disclosed |
| WO-2022261250-A1 | THERAPEUTICS FOR THE DEGRADATION OF MUTANT BRAF | C4 THERAPEUTICS, INC. (US) | 2022-12-15 | — | — | WO | disclosed |