Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 12/20 | 0.50 |
| ▸ | CRBN | Q96SW2 | 12/20 | 0.50 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.38 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.38 |
| ▸ | IKZF2 | Q9UKS7 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.35 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31323655 | 0.99 | DDB1 (0.49) | DDB1CRBNTNKSPARP1PARP2 | |
| SCHEMBL31323682 | 0.99 | DDB1 (0.49) | DDB1CRBNTNKSPARP1PARP2 | |
| SCHEMBL31323706 | 0.95 | DDB1 (0.52) | DDB1CRBNTNKSPARP1PARP2 | |
| SCHEMBL26634850 | 0.91 | DDB1 (0.50) | DDB1CRBNTNKSPARP1PARP2 | |
| SCHEMBL31494633 | 0.90 | DDB1 (0.47) | DDB1CRBNTNKSPARP1PARP2 | |
| SCHEMBL23540197 | 0.86 | DDB1 (0.55) | DDB1CRBNIKZF2 | |
| SCHEMBL31003857 | 0.84 | DDB1 (0.46) | DDB1CRBN | |
| SCHEMBL30258585 | 0.83 | DDB1 (0.54) | DDB1CRBNTNKSPARP1PARP2 | |
| SCHEMBL24873004 | 0.82 | CRBN (0.63) | DDB1CRBNALDH1A1 | |
| SCHEMBL31323759 | 0.82 | DDB1 (0.53) | DDB1CRBNTNKSPARP1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4735452-A2 | HETEROBIFUNCTIONAL COMPOUNDS FOR THE DEGRADATION OF KRAS PROTEIN | Merck Patent GmbH (DE) | 2026-05-06 | — | — | EP | disclosed |
| WO-2025006753-A2 | HETEROBIFUNCTIONAL COMPOUNDS FOR THE DEGRADATION OF KRAS PROTEIN | MERCK PATENT GMBH (DE) | 2025-01-02 | — | — | WO | disclosed |