SCHEMBL31325969

SCHEMBL31325969

O=C(O)c1nc(Br)c2ccccn12

nearest known ligand 0.43

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAP2K3 P46734 2/20 0.43
PTGS2 P35354 4/20 0.42
PTGS1 P23219 3/20 0.42
FNTA P49354 2/20 0.42
FNTB P49356 2/20 0.42
RORC P51449 7/20 0.42
SSTR4 P31391 1/20 0.41
MAPK14 Q16539 1/20 0.40
KDM4E B2RXH2 1/20 0.40
MEN1 O00255 1/20 0.40
ALDH1A1 P00352 1/20 0.40
MAPT P10636 1/20 0.40
KMT2A Q03164 1/20 0.40
POLB P06746 1/20 0.40
HPGD P15428 1/20 0.40
MAPK1 P28482 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
IDO1 P14902 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18031312 0.86 KMT2A (0.44) MAP2K3SSTR4MAPK14KDM4EMEN1
SCHEMBL26684420 0.86 MAP2K3 (0.58) MAP2K3PTGS2PTGS1FNTAFNTB
SCHEMBL18033609 0.82 SSTR4 (0.40) MAP2K3RORCSSTR4MAPK14POLB
SCHEMBL18399874 0.79 RORC (0.44) RORCSSTR4
SCHEMBL4318706 0.79 KDM4E (0.54) PTGS2PTGS1KDM4EMEN1ALDH1A1
SCHEMBL16569368 0.79 RORC (0.61) RORC
SCHEMBL29805590 0.79 PTPN1 (0.51) MAP2K3PTGS2PTGS1FNTAFNTB
SCHEMBL321531 0.78 FNTA (0.46) FNTAFNTBRORCKDM4EALDH1A1
SCHEMBL19795725 0.76 MAP2K3 (0.51) MAP2K3PTGS2PTGS1FNTAFNTB
SCHEMBL4321632 0.76 CNR1 (0.59) RORCMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4713323-A1 3-CARBONYL IMIDAZO[1,5-A]PYRIDINE DERIVATIVES FOR USE AS CD38 INHIBITORS FOR THE TREATMENT OF CNS DISORDERS Cerevance, Inc. (US) 2026-03-25 EP disclosed
CN-119421876-A Compounds and medicaments as DDR1 kinase inhibitors 日本新药株式会社 2025-02-11 CN disclosed
WO-2024236316-A1 3-CARBONYL IMIDAZO[1,5-A]PYRIDINE DERIVATIVES FOR USE AS CD38 INHIBITORS FOR THE TREATMENT OF CNS DISORDERS Cerevance, Inc. (US) 2024-11-21 WO disclosed