Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 9/20 | 1.00 |
| ▸ | HPGDS | O60760 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | LDLR | P01130 | 1/20 | 0.44 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 3/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | HTR7 | P34969 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20646497 | 0.79 | IDO1 (0.66) | IDO1HPGDSMEN1ALDH1A1KMT2A | |
| SCHEMBL1501923 | 0.77 | IDO1 (0.67) | IDO1HTR6HTR2AHTR1AHTR7 | |
| SCHEMBL1501988 | 0.77 | IDO1 (0.63) | IDO1KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL1948762 | 0.76 | IDO1 (0.69) | IDO1KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL16720659 | 0.76 | IDO1 (0.61) | IDO1HPGDSLDLRPCSK9HTR6 | |
| SCHEMBL3710027 | 0.75 | HTR2C (0.61) | IDO1HPGDSKDM4ELDLRPCSK9 | |
| SCHEMBL1133101 | 0.75 | IDO1 (0.60) | IDO1HPGDSALDH1A1MAPTLDLR | |
| SCHEMBL21566711 | 0.75 | IDO1 (0.60) | IDO1HPGDSLDLRPCSK9HTR6 | |
| SCHEMBL1948414 | 0.75 | IDO1 (1.00) | IDO1KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL19732321 | 0.73 | IDO1 (0.57) | IDO1HPGDSLDLRPCSK9HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113166114-B | Cyclic tetramer compounds as inhibitors of proprotein convertase subtilisin/KEXIN type 9 (PCSK 9) for the treatment of metabolic disorders | 诺华股份有限公司 | 2025-01-03 | — | — | CN | disclosed |