Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.61 |
| ▸ | IDO1 | P14902 | 4/20 | 0.60 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.58 |
| ▸ | HPGDS | O60760 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LDLR | P01130 | 1/20 | 0.42 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | FNTA | P49354 | 1/20 | 0.42 |
| ▸ | FNTB | P49356 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27794063 | 0.79 | CYP11B2 (0.58) | HTR2CIDO1CYP11B2KDM4E | |
| SCHEMBL27794035 | 0.79 | CYP11B2 (0.58) | HTR2CIDO1CYP11B2KDM4ECYP1A2 | |
| SCHEMBL15507748 | 0.77 | TTK (0.48) | HTR2CIDO1CYP11B2HPGDSLDLR | |
| SCHEMBL30132183 | 0.77 | TTK (0.48) | HTR2CIDO1CYP11B2HPGDSLDLR | |
| SCHEMBL20646497 | 0.77 | IDO1 (0.66) | HTR2CIDO1CYP11B2HPGDSLDLR | |
| SCHEMBL31326499 | 0.75 | IDO1 (1.00) | HTR2CIDO1HPGDSKDM4ELDLR | |
| SCHEMBL19732321 | 0.74 | IDO1 (0.57) | HTR2CIDO1CYP11B2HPGDSLDLR | |
| SCHEMBL3534128 | 0.73 | CYP11B2 (1.00) | HTR2CIDO1CYP11B2KDM4E | |
| SCHEMBL21128564 | 0.73 | IDO1 (0.57) | HTR2CIDO1CYP11B2HPGDSLDLR | |
| SCHEMBL18361608 | 0.72 | IDO1 (0.60) | HTR2CIDO1HPGDSKDM4ELDLR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120122780-A1 | Compounds, Compositions and Methods for Modulating Uric Acid Levels | ARDEA BIOSCIENCES INC. (US) | 2012-05-17 | — | — | US | disclosed |
| US-20120122780-A1 | Compounds, Compositions and Methods for Modulating Uric Acid Levels | ARDEA BIOSCIENCES INC. (US) | 2012-05-17 | — | — | US | disclosed |
| US-20120122780-A1 | Compounds, Compositions and Methods for Modulating Uric Acid Levels | ARDEA BIOSCIENCES INC. (US) | 2012-05-17 | — | — | US | disclosed |
| WO-2010135530-A2 | COMPOUNDS, COMPOSITIONS AND METHODS FOR MODULATING URIC ACID LEVELS | ARDEA BIOSCIENCES, INC. (US) | 2010-11-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122780-A1 | Compounds, Compositions and Methods for Modulating Uric Acid Levels | XDH, PON1, RBP4 | HTR2C 2968/4885IDO1 1821/4885CYP11B2 778/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.