Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 6/20 | 0.63 |
| ▸ | GUSB | P08236 | 6/20 | 0.53 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.45 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1252723 | 1.00 | DGAT1 (0.63) | DGAT1GUSBSIRT2SIRT1SIRT3 | |
| SCHEMBL1252769 | 0.91 | DGAT1 (0.59) | DGAT1GUSBSIRT2SIRT1SIRT3 | |
| SCHEMBL1252108 | 0.91 | DGAT1 (0.65) | DGAT1GUSBSIRT2SIRT1SIRT3 | |
| SCHEMBL1250496 | 0.84 | DGAT1 (0.80) | DGAT1GUSBSIRT2SIRT1SIRT3 | |
| SCHEMBL1252809 | 0.83 | DGAT1 (0.62) | DGAT1GUSBSIRT2SIRT1SIRT3 | |
| SCHEMBL10299681 | 0.81 | DGAT1 (0.81) | DGAT1GUSBSIRT2SIRT1SIRT3 | |
| SCHEMBL1252721 | 0.80 | DGAT1 (0.79) | DGAT1GUSBMAPTEGFRERBB2 | |
| SCHEMBL1252216 | 0.78 | DGAT1 (1.00) | DGAT1GUSBCHEK2 | |
| SCHEMBL30385298 | 0.78 | DGAT1 (1.00) | DGAT1GUSBCHEK2 | |
| SCHEMBL30385333 | 0.78 | DGAT1 (0.60) | DGAT1GUSBSIRT2SIRT1SIRT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113166204-B | Cyclic peptides as inhibitors of proprotein convertase subtilisin/kexin type 9 (PCSK 9) for the treatment of metabolic disorders | 诺华股份有限公司 | 2025-01-28 | — | — | CN | disclosed |
| CN-113166114-B | Cyclic tetramer compounds as inhibitors of proprotein convertase subtilisin/KEXIN type 9 (PCSK 9) for the treatment of metabolic disorders | 诺华股份有限公司 | 2025-01-03 | — | — | CN | disclosed |