Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.66 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | AKT1 | P31749 | 6/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 3/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1598149 | 1.00 | CHEK1 (0.66) | CHEK1NOTUMAKT1TRPA1LRRK2 | |
| SCHEMBL23735452 | 0.81 | CHEK1 (0.48) | CHEK1NOTUMAKT1TRPA1LRRK2 | |
| SCHEMBL2323682 | 0.81 | CHEK1 (0.63) | CHEK1NOTUMAKT1TRPA1LRRK2 | |
| SCHEMBL153752 | 0.81 | CHEK1 (0.63) | CHEK1NOTUMAKT1TRPA1LRRK2 | |
| SCHEMBL5019486 | 0.79 | CHEK1 (0.61) | CHEK1NOTUMAKT1TRPA1LRRK2 | |
| SCHEMBL357993 | 0.79 | CHEK1 (0.61) | CHEK1NOTUMAKT1TRPA1BRAF | |
| SCHEMBL2321413 | 0.79 | CHEK1 (0.61) | CHEK1NOTUMAKT1TRPA1LRRK2 | |
| SCHEMBL154600 | 0.79 | CHEK1 (0.61) | CHEK1NOTUMAKT1TRPA1BRAF | |
| SCHEMBL61206 | 0.79 | CHEK1 (1.00) | CHEK1NOTUMAKT1TRPA1LRRK2 | |
| SCHEMBL21620551 | 0.79 | CHEK1 (0.47) | CHEK1NOTUMAKT1TRPA1LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025043151-A2 | BICYCLIC DGK INHIBITORS | INCYTE CORPORATION (US) | 2025-02-27 | — | — | WO | disclosed |