Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.70 |
| ▸ | RAB9A | P51151 | 10/20 | 0.70 |
| ▸ | MEN1 | O00255 | 3/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | PKM | P14618 | 3/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.70 |
| ▸ | MAOB | P27338 | 1/20 | 0.70 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.70 |
| ▸ | MMP2 | P08253 | 1/20 | 0.67 |
| ▸ | MMP9 | P14780 | 1/20 | 0.67 |
| ▸ | MMP8 | P22894 | 1/20 | 0.67 |
| ▸ | MMP13 | P45452 | 1/20 | 0.67 |
| ▸ | SCD | O00767 | 1/20 | 0.64 |
| ▸ | MTOR | P42345 | 1/20 | 0.57 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.56 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31329341 | 0.91 | NPC1 (0.81) | NPC1RAB9AMEN1KMT2APKM | |
| SCHEMBL31329345 | 0.86 | NPC1 (0.74) | NPC1RAB9AMEN1KMT2APKM | |
| SCHEMBL6126187 | 0.84 | EGLN1 (0.53) | NPC1RAB9AMEN1KMT2AMMP2 | |
| SCHEMBL9953971 | 0.84 | SMN1; SMN2 (0.65) | NPC1RAB9AMEN1KMT2APKM | |
| SCHEMBL30369772 | 0.84 | NPC1 (0.71) | NPC1RAB9AMEN1KMT2APKM | |
| SCHEMBL5744080 | 0.84 | NPC1 (0.70) | NPC1RAB9AMEN1KMT2APKM | |
| SCHEMBL11707756 | 0.84 | NPC1 (0.71) | NPC1RAB9AMEN1KMT2APKM | |
| SCHEMBL31329343 | 0.83 | NPC1 (0.78) | NPC1RAB9AMEN1KMT2APKM | |
| SCHEMBL3926899 | 0.83 | NPC1 (1.00) | NPC1RAB9AMEN1KMT2APKM | |
| SCHEMBL31329354 | 0.83 | NPC1 (1.00) | NPC1RAB9AMEN1KMT2APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119330886-A | Benzimidazole amine derivative, preparation method thereof and beta2Use of allosteric antagonists of adrenergic receptors | 常州大学 | 2025-01-21 | — | — | CN | disclosed |
| CN-119318653-A | Application of benzimidazole amine derivatives in medicines for preventing/treating non-alcoholic fatty liver disease | 常州大学 | 2025-01-17 | — | — | CN | disclosed |